Visible light is able to regulate neurite outgrowth

Akon Higuchi, Hanako Kitamura, Ko Ichi Shishimine, Sousuke Konishi, Boo Ok Yoon, Mariko Hara

研究成果: 雜誌貢獻期刊論文同行評審

20 引文 斯高帕斯(Scopus)


The pheochromocytoma cell line PC12 displays neuronal characteristics. PC12 cells differentiate their phenotype from a proliferating cell to a neurite-bearing neuron upon treatment with nerve growth factor (NGF). The neurite outgrowth of PC12 cells on polystyrene tissue culture flasks and extracellular matrix protein-adsorbed glass plates was reversibly controlled using visible light. The percentage of cells with neurites decreased with increasing light intensity. Furthermore, neurite outgrowth was dramatically suppressed with light intensities over 300 Lux (approximately 130 μW). Neurite outgrowth occurred in the absence of irradiation by visible light, but did not occur or was limited with irradiation, depending on the membranes on which PC12 cells were cultured. These results hold promise for the creation of patterned neuronal networks corresponding to patterned irradiation of visible light on nerve cells.

頁(從 - 到)1377-1388
期刊Journal of Biomaterials Science, Polymer Edition
出版狀態已出版 - 2003


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