Unconventional separation of arsenic trioxide from unused aqueous chemotherapeutic agents by direct evaporative crystallization

Dhanang Edy Pratama; Wen Chen Hsieh; Kuan Yun Lin; Yu Ying Chen; Chun Chou Lin; Tu Lee; Yufang Hu

doi:10.1080/01496395.2020.1837876

Unconventional separation of arsenic trioxide from unused aqueous chemotherapeutic agents by direct evaporative crystallization

Dhanang Edy Pratama, Wen Chen Hsieh, Kuan Yun Lin, Yu Ying Chen, Chun Chou Lin, Tu Lee, Yufang Hu

化學工程與材料工程學系

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

摘要

An unconventional arsenic trioxide (As₂O₃) recovery process for unused injectable aqueous chemotherapeutic agents for leukemia treatment, having a concentration of 2 mg of As₂O₃/mL of H₂O, was used as a case study by evaporative crystallization in a closed system under the pressures of 0.4, 0.7 and 1.0 atm. The yields for As₂O₃ solids recovered were 60 to 90 wt% with a purity in conformity with the As₂O₃ standard based on an HPLC assay. The recovered As₂O₃ solids were determined to be the arsenolite phase by PXRD with a particle size range of <10 μm.

原文	???core.languages.en_GB???
頁（從 - 到）	2634-2647
頁數	14
期刊	Separation Science and Technology
卷	56
發行號	15
DOIs	https://doi.org/10.1080/01496395.2020.1837876
出版狀態	已出版 - 2021

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10.1080/01496395.2020.1837876

藥物循環經濟：使用溶劑萃取和再結晶從各種藥物中回收活性藥物成分(2/2)
Lee, T. (PI)
1/12/19 → 30/11/20
研究計畫: Research
藥物循環經濟 : 使用溶劑萃取和再結晶從各種藥物中回收活性藥物成分(2/2)
Lee, T. (PI)
1/12/19 → 30/11/20
研究計畫: Research

Unconventional separation of arsenic trioxide from unused aqueous chemotherapeutic agents by direct evaporative crystallization
Pratama, D. E. (貢獻者), Hsieh, W.-C. (貢獻者), Lin, K.-Y. (貢獻者), Lee, T. (貢獻者), Chen, Y.-Y. (貢獻者), Hu, Y. (貢獻者) & Lin, C.-C. (貢獻者), figshare Academic Research System, 1 1月 2020
DOI: 10.6084/m9.figshare.13168155.v1, https://tandf.figshare.com/articles/journal_contribution/Unconventional_separation_of_arsenic_trioxide_from_unused_aqueous_chemotherapeutic_agents_by_direct_evaporative_crystallization/13168155/1
資料集

引用此

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title = "Unconventional separation of arsenic trioxide from unused aqueous chemotherapeutic agents by direct evaporative crystallization",

abstract = "An unconventional arsenic trioxide (As2O3) recovery process for unused injectable aqueous chemotherapeutic agents for leukemia treatment, having a concentration of 2 mg of As2O3/mL of H2O, was used as a case study by evaporative crystallization in a closed system under the pressures of 0.4, 0.7 and 1.0 atm. The yields for As2O3 solids recovered were 60 to 90 wt% with a purity in conformity with the As2O3 standard based on an HPLC assay. The recovered As2O3 solids were determined to be the arsenolite phase by PXRD with a particle size range of <10 μm.",

keywords = "Arsenic recovery, Evaporative crystallization, Unused chemotherapeutic agents",

author = "Pratama, {Dhanang Edy} and Hsieh, {Wen Chen} and Lin, {Kuan Yun} and Chen, {Yu Ying} and Lin, {Chun Chou} and Tu Lee and Yufang Hu",

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AU - Pratama, Dhanang Edy

AU - Hsieh, Wen Chen

AU - Lin, Kuan Yun

AU - Chen, Yu Ying

AU - Lin, Chun Chou

AU - Lee, Tu

AU - Hu, Yufang

PY - 2021

Y1 - 2021

N2 - An unconventional arsenic trioxide (As2O3) recovery process for unused injectable aqueous chemotherapeutic agents for leukemia treatment, having a concentration of 2 mg of As2O3/mL of H2O, was used as a case study by evaporative crystallization in a closed system under the pressures of 0.4, 0.7 and 1.0 atm. The yields for As2O3 solids recovered were 60 to 90 wt% with a purity in conformity with the As2O3 standard based on an HPLC assay. The recovered As2O3 solids were determined to be the arsenolite phase by PXRD with a particle size range of <10 μm.

AB - An unconventional arsenic trioxide (As2O3) recovery process for unused injectable aqueous chemotherapeutic agents for leukemia treatment, having a concentration of 2 mg of As2O3/mL of H2O, was used as a case study by evaporative crystallization in a closed system under the pressures of 0.4, 0.7 and 1.0 atm. The yields for As2O3 solids recovered were 60 to 90 wt% with a purity in conformity with the As2O3 standard based on an HPLC assay. The recovered As2O3 solids were determined to be the arsenolite phase by PXRD with a particle size range of <10 μm.

KW - Arsenic recovery

KW - Evaporative crystallization

KW - Unused chemotherapeutic agents

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M3 - 期刊論文

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SN - 0149-6395

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EP - 2647

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JF - Separation Science and Technology

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ER -

Unconventional separation of arsenic trioxide from unused aqueous chemotherapeutic agents by direct evaporative crystallization

摘要

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指紋

專案

藥物循環經濟：使用溶劑萃取和再結晶從各種藥物中回收活性藥物成分(2/2)

藥物循環經濟 : 使用溶劑萃取和再結晶從各種藥物中回收活性藥物成分(2/2)

資料集

Unconventional separation of arsenic trioxide from unused aqueous chemotherapeutic agents by direct evaporative crystallization

引用此