Towards the discovery of diseases related by genes using vertex similarity measures

Hung Hsuan Chen, Liang Gou, Xiaolong Luke Zhang, C. Lee Giles

研究成果: 書貢獻/報告類型會議論文篇章同行評審

3 引文 斯高帕斯(Scopus)

摘要

Discovering the relationships of gene to gene, gene to its related diseases, and diseases implicated in common genes is important. However, traditional biological methods can be expensive. Here, we show that the diseases implicated in common genes and the genes related to a multiple-gene disease can be inferred by the vertex similarity measures, a type of method to find the similar vertices in a network based on its structure. The relationship among diseases and the relationship among genes are modeled as two biological networks: human disease network and disease gene network. We apply the vertex similarity among the vertices in the human disease network to infer the diseases implicated in common genes. By similar manner, we utilize vertex similarity measures on the disease gene network to infer the genes related to a common multiple-gene disease. Experimental results demonstrate the potential of vertex similarity as an inexpensive approach to infer the possible links between genes and between diseases. We also develop a system to visualize and get a better understanding about the relationships among diseases and genes.

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主出版物標題Proceedings - 2013 IEEE International Conference on Healthcare Informatics, ICHI 2013
頁面505-510
頁數6
DOIs
出版狀態已出版 - 2013
事件2013 1st IEEE International Conference on Healthcare Informatics, ICHI 2013 - Philadelphia, PA, United States
持續時間: 9 9月 201311 9月 2013

出版系列

名字Proceedings - 2013 IEEE International Conference on Healthcare Informatics, ICHI 2013

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???event.eventtypes.event.conference???2013 1st IEEE International Conference on Healthcare Informatics, ICHI 2013
國家/地區United States
城市Philadelphia, PA
期間9/09/1311/09/13

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