Topical vaccination: The skin as a unique portal to adaptive immune responses

Chun Ming Huang

研究成果: 雜誌貢獻回顧評介論文同行評審

22 引文 斯高帕斯(Scopus)

摘要

Skin is an ideal tissue for vaccine administration, as it is comprised of immunocompetent cells such as keratinocytes and Langerhans cells and elicits both innate and adaptive immune responses. In this paper, we summarize the immune responses induced by topical vaccination of the skin and review the effects of adjuvants on skin vaccination. We also summarize the existing techniques for skin vaccination. New techniques such as the use of lasers to enhance skin permeability are also discussed, as well as the role of the stratum corneum in skin vaccination. A recent study demonstrating enhanced skin vaccination by using surfactants to extract partial lamellar lipids of the stratum corneum will also be introduced in this review.

原文???core.languages.en_GB???
頁(從 - 到)71-80
頁數10
期刊Seminars in Immunopathology
29
發行號1
DOIs
出版狀態已出版 - 4月 2007

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