@article{7d577b68f99d45e4a64d4e372c97e22f,
title = "Toll-like receptor 3 expression inhibits cell invasion and migration and predicts a favorable prognosis in neuroblastoma",
abstract = "To evaluate the clinical significance of TLR3 expression on neuroblastomas, we performed immunohistochemical study on archival tissues and in vitro studies on neuroblastoma cell lines. The results showed that positive TLR3 expression was associated with favorable histology and prognosis. Activation of TLR3 by polyinosinic:polycytidylic acid [poly(I:C)] treatment is effective to suppress cell migration and invasion and to decrease organized assembly of F-actin and filopodia formation, in TLR3-expressing SK-N-AS cells, which could be reversed by TLR3-targeting siRNA treatment. TLR3 agonist poly(I:C) promotes GAP-43 expression also in SK-N-AS cells only. Taken together, TLR3 could serve to predict favorable behavior in neuroblastomas.",
keywords = "Migration, Neuroblastoma, Poly(I:C), Prognosis, Toll-like receptor 3",
author = "Hsu, {Wen Ming} and Huang, {Chao Cheng} and Wu, {Pei Yi} and Hsinyu Lee and Huang, {Min Chuan} and Tai, {Ming Hong} and Chuang, {Jiin Haur}",
note = "Funding Information: The authors wish to thank Ms. Chia-Ling Wu and Chang Gung Medical Foundation Kaohsiung Chang Gung Memorial Hospital Tissue Bank (CLRPG8B0031) for excellent technical support, and Vanessa Yu of Taiwan Instrument Co., Ltd., for her assistance in using confocal laser microscopy. This study was supported by the Grants from the Chang Gung Memorial Hospital (CMRPG890303 & CMRPG891091). ",
year = "2013",
month = aug,
day = "19",
doi = "10.1016/j.canlet.2013.03.024",
language = "???core.languages.en_GB???",
volume = "336",
pages = "338--346",
journal = "Cancer Letters",
issn = "0304-3835",
number = "2",
}
