Titanium complexes bearing 2,6-bis(o-hydroxyalkyl)pyridine ligands in vitro cytotoxicity against triple-negative breast-cancer cells

I. Ni Chen, Prasanna Kumar Ganta, Shou Jie Chung, Yu Lun Chang, Heng Yi Chang, Shangwu Ding, Hsuan Ying Chen, Chien Chih Chiu, Kuo Hui Wu

研究成果: 雜誌貢獻期刊論文同行評審

摘要

Three titanium (Ti) compounds bearing 2,6-bis(o-hydroxyalkyl)pyridine ligands were synthesized, and used in vitro cytotoxicity against triple-negative breast cancer (TNBC) MDA-MB-231 cells was studied. The results of in vitro cytotoxicity of the complexes against TNBC cells revealed that (HLMeTi-O)4 (IC50 = 0.91 μM) exerted a significant inhibitory effect on the proliferation of TNBC cells. Thus, titanium alkoxide complexes as nonplatinum complex could be used for structural optimization for treating breast cancer cells in the future.

原文???core.languages.en_GB???
頁(從 - 到)871-877
頁數7
期刊Journal of the Chinese Chemical Society
68
發行號5
DOIs
出版狀態已出版 - 5月 2021

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