@article{71499c454b4541189ce8f52ee8be462f,
title = "Titanium complexes bearing 2,6-bis(o-hydroxyalkyl)pyridine ligands in vitro cytotoxicity against triple-negative breast-cancer cells",
abstract = "Three titanium (Ti) compounds bearing 2,6-bis(o-hydroxyalkyl)pyridine ligands were synthesized, and used in vitro cytotoxicity against triple-negative breast cancer (TNBC) MDA-MB-231 cells was studied. The results of in vitro cytotoxicity of the complexes against TNBC cells revealed that (HLMeTi-O)4 (IC50 = 0.91 μM) exerted a significant inhibitory effect on the proliferation of TNBC cells. Thus, titanium alkoxide complexes as nonplatinum complex could be used for structural optimization for treating breast cancer cells in the future.",
keywords = "2,6-bis(o-hydroxyalkyl)pyridine ligand, in vitro cytotoxicity, nonplatinum complex, pincer complexes, titanium complex, TNBC cell",
author = "Chen, {I. Ni} and Ganta, {Prasanna Kumar} and Chung, {Shou Jie} and Chang, {Yu Lun} and Chang, {Heng Yi} and Shangwu Ding and Chen, {Hsuan Ying} and Chiu, {Chien Chih} and Wu, {Kuo Hui}",
note = "Publisher Copyright: {\textcopyright} 2021 The Chemical Society Located in Taipei & Wiley-VCH GmbH",
year = "2021",
month = may,
doi = "10.1002/jccs.202000393",
language = "???core.languages.en_GB???",
volume = "68",
pages = "871--877",
journal = "Journal of the Chinese Chemical Society",
issn = "0009-4536",
number = "5",
}
