Time-course gene expression profiling of high glucose-induced endothelial cell apoptosis

Julia Tzu Ya Weng; Yi Cheng Chen; Chung Hsien Ma; Tzung Shian Lai; Feng Ming Ho

doi:10.1109/ISBB.2014.6820924

Time-course gene expression profiling of high glucose-induced endothelial cell apoptosis

Julia Tzu Ya Weng, Yi Cheng Chen, Chung Hsien Ma, Tzung Shian Lai, Feng Ming Ho

資訊管理學系

研究成果: 書貢獻/報告類型 › 會議論文篇章 › 同行評審

摘要

Diabetes is a debilitating metabolic disorder resulting from hyperglycemia and glucose intolerance. High glucose-induced endothelial dysfunction is an important contributor to vascular disease in diabetes. In this study, we profiled the global gene expression changes in human umbilical vein endothelial cells treated with high glucose at the 0-, 24-, and 48-hour intervals. Differentially expressed genes were examined through bioinformatics analysis for potential mechanisms of regulation. Our analysis uncovered novel regulatory interactions that may provide insights into the molecular transition from normal cellular activities to apoptosis under high glucose, enhancing our understanding of the mechanisms underlying vascular complications in diabetic patients.

原文	???core.languages.en_GB???
主出版物標題	2014 IEEE International Symposium on Bioelectronics and Bioinformatics, IEEE ISBB 2014
發行者	IEEE Computer Society
ISBN（列印）	9781479927708
DOIs	https://doi.org/10.1109/ISBB.2014.6820924
出版狀態	已出版 - 2014
事件	2014 IEEE International Symposium on Bioelectronics and Bioinformatics, IEEE ISBB 2014 - Chung Li, Taiwan 持續時間: 11 4月 2014 → 14 4月 2014

出版系列

名字	2014 IEEE International Symposium on Bioelectronics and Bioinformatics, IEEE ISBB 2014

???event.eventtypes.event.conference???

???event.eventtypes.event.conference???	2014 IEEE International Symposium on Bioelectronics and Bioinformatics, IEEE ISBB 2014
國家/地區	Taiwan
城市	Chung Li
期間	11/04/14 → 14/04/14

UN SDG

此研究成果有助於以下永續發展目標

存取文件

10.1109/ISBB.2014.6820924

引用此

Weng, J. T. Y., Chen, Y. C., Ma, C. H., Lai, T. S., & Ho, F. M. (2014). Time-course gene expression profiling of high glucose-induced endothelial cell apoptosis. 於 2014 IEEE International Symposium on Bioelectronics and Bioinformatics, IEEE ISBB 2014 Article 6820924 (2014 IEEE International Symposium on Bioelectronics and Bioinformatics, IEEE ISBB 2014). IEEE Computer Society. https://doi.org/10.1109/ISBB.2014.6820924

@inproceedings{3ad5ff6149174e7c9ebaddf9323ff29e,

title = "Time-course gene expression profiling of high glucose-induced endothelial cell apoptosis",

abstract = "Diabetes is a debilitating metabolic disorder resulting from hyperglycemia and glucose intolerance. High glucose-induced endothelial dysfunction is an important contributor to vascular disease in diabetes. In this study, we profiled the global gene expression changes in human umbilical vein endothelial cells treated with high glucose at the 0-, 24-, and 48-hour intervals. Differentially expressed genes were examined through bioinformatics analysis for potential mechanisms of regulation. Our analysis uncovered novel regulatory interactions that may provide insights into the molecular transition from normal cellular activities to apoptosis under high glucose, enhancing our understanding of the mechanisms underlying vascular complications in diabetic patients.",

keywords = "diabetes, gene expression, high glucose, time-course analysis",

author = "Weng, {Julia Tzu Ya} and Chen, {Yi Cheng} and Ma, {Chung Hsien} and Lai, {Tzung Shian} and Ho, {Feng Ming}",

year = "2014",

doi = "10.1109/ISBB.2014.6820924",

language = "???core.languages.en_GB???",

isbn = "9781479927708",

series = "2014 IEEE International Symposium on Bioelectronics and Bioinformatics, IEEE ISBB 2014",

publisher = "IEEE Computer Society",

booktitle = "2014 IEEE International Symposium on Bioelectronics and Bioinformatics, IEEE ISBB 2014",

note = "2014 IEEE International Symposium on Bioelectronics and Bioinformatics, IEEE ISBB 2014 ; Conference date: 11-04-2014 Through 14-04-2014",

}

Weng, JTY, Chen, YC, Ma, CH, Lai, TS & Ho, FM 2014, Time-course gene expression profiling of high glucose-induced endothelial cell apoptosis. 於 2014 IEEE International Symposium on Bioelectronics and Bioinformatics, IEEE ISBB 2014., 6820924, 2014 IEEE International Symposium on Bioelectronics and Bioinformatics, IEEE ISBB 2014, IEEE Computer Society, 2014 IEEE International Symposium on Bioelectronics and Bioinformatics, IEEE ISBB 2014, Chung Li, Taiwan, 11/04/14. https://doi.org/10.1109/ISBB.2014.6820924

Time-course gene expression profiling of high glucose-induced endothelial cell apoptosis. / Weng, Julia Tzu Ya; Chen, Yi Cheng; Ma, Chung Hsien 等.
2014 IEEE International Symposium on Bioelectronics and Bioinformatics, IEEE ISBB 2014. IEEE Computer Society, 2014. 6820924 (2014 IEEE International Symposium on Bioelectronics and Bioinformatics, IEEE ISBB 2014).

研究成果: 書貢獻/報告類型 › 會議論文篇章 › 同行評審

TY - GEN

T1 - Time-course gene expression profiling of high glucose-induced endothelial cell apoptosis

AU - Weng, Julia Tzu Ya

AU - Chen, Yi Cheng

AU - Ma, Chung Hsien

AU - Lai, Tzung Shian

AU - Ho, Feng Ming

PY - 2014

Y1 - 2014

N2 - Diabetes is a debilitating metabolic disorder resulting from hyperglycemia and glucose intolerance. High glucose-induced endothelial dysfunction is an important contributor to vascular disease in diabetes. In this study, we profiled the global gene expression changes in human umbilical vein endothelial cells treated with high glucose at the 0-, 24-, and 48-hour intervals. Differentially expressed genes were examined through bioinformatics analysis for potential mechanisms of regulation. Our analysis uncovered novel regulatory interactions that may provide insights into the molecular transition from normal cellular activities to apoptosis under high glucose, enhancing our understanding of the mechanisms underlying vascular complications in diabetic patients.

AB - Diabetes is a debilitating metabolic disorder resulting from hyperglycemia and glucose intolerance. High glucose-induced endothelial dysfunction is an important contributor to vascular disease in diabetes. In this study, we profiled the global gene expression changes in human umbilical vein endothelial cells treated with high glucose at the 0-, 24-, and 48-hour intervals. Differentially expressed genes were examined through bioinformatics analysis for potential mechanisms of regulation. Our analysis uncovered novel regulatory interactions that may provide insights into the molecular transition from normal cellular activities to apoptosis under high glucose, enhancing our understanding of the mechanisms underlying vascular complications in diabetic patients.

KW - diabetes

KW - gene expression

KW - high glucose

KW - time-course analysis

UR - http://www.scopus.com/inward/record.url?scp=84904548535&partnerID=8YFLogxK

U2 - 10.1109/ISBB.2014.6820924

DO - 10.1109/ISBB.2014.6820924

M3 - 會議論文篇章

AN - SCOPUS:84904548535

SN - 9781479927708

T3 - 2014 IEEE International Symposium on Bioelectronics and Bioinformatics, IEEE ISBB 2014

BT - 2014 IEEE International Symposium on Bioelectronics and Bioinformatics, IEEE ISBB 2014

PB - IEEE Computer Society

T2 - 2014 IEEE International Symposium on Bioelectronics and Bioinformatics, IEEE ISBB 2014

Y2 - 11 April 2014 through 14 April 2014

ER -

Weng JTY, Chen YC, Ma CH, Lai TS, Ho FM. Time-course gene expression profiling of high glucose-induced endothelial cell apoptosis. 於 2014 IEEE International Symposium on Bioelectronics and Bioinformatics, IEEE ISBB 2014. IEEE Computer Society. 2014. 6820924. (2014 IEEE International Symposium on Bioelectronics and Bioinformatics, IEEE ISBB 2014). doi: 10.1109/ISBB.2014.6820924

Time-course gene expression profiling of high glucose-induced endothelial cell apoptosis

摘要

出版系列

???event.eventtypes.event.conference???

UN SDG

存取文件

指紋

引用此