In this study, we proposed a game-based anti-drug system to assist people to understand the danger of drug abuse. In addition, we also examined how people's drug experience affected their reactions to the game-based anti-drug system. Thirty people, aged from 23 to 39, participated in this study and was classified into two groups, i.e., addictive people (N=14) and non-Addictive people (N=16). Log files and a perception questionnaire were employed to collect and analyze participants' learning behaviors and learning perceptions, respectively. The results revealed that drug experience might affect people's reactions to the game-based anti-drug system. More specifically, the addictive people more focused on anti-drug materials while the non-Addictive people emphasized on digital games, regardless of learning behaviors or learning perceptions.