The cooperative nature of hydrophobic forces and protein folding kinetics

Jin Wang, Chilun Lee, George Stell

研究成果: 雜誌貢獻期刊論文同行評審

12 引文 斯高帕斯(Scopus)

摘要

We study the effects of cooperative forces on protein folding kinetics using statistical energy landscape theory. We find that the mean first passage time for folding changes the shape from V to U-like curve dependence on the temperature when the effects of the cooperative forces are important, which is consistent with kinetic experiments. This supports the necessity for cooperative force. In addition, we find that cooperative forces tend to increase the free energy barrier so the kinetics is in general slower. Furthermore, we find that cooperative forces tend to suppress the fluctuations in kinetics more than non-cooperative forces. The cooperativity causes to the protein folding kinetics to be more two state-like.

原文???core.languages.en_GB???
頁(從 - 到)53-60
頁數8
期刊Chemical Physics
316
發行號1-3
DOIs
出版狀態已出版 - 19 9月 2005

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