The association of ambient air pollution with airway inflammation in schoolchildren

Bing Yu Chen, Chang Chuan Chan, Chung Te Lee, Tsun Jen Cheng, Wen Chuan Huang, Ji Ci Jhou, Yueh Ying Han, Chu Chih Chen, Yue Leon Guo

研究成果: 雜誌貢獻期刊論文同行評審

35 引文 斯高帕斯(Scopus)

摘要

The biologic mechanisms involved in airway inflammatory response to air pollution are not clearly understood. The authors conducted a longitudinal study to investigate whether exposure to ambient air pollutants affected inflammatory cells and mediators from nasal lavage in schoolchildren. Study participants were 100 elementary and middle-school students in New Taipei City, Taiwan. A structured respiratory health questionnaire was administered in September 2007, followed by monthly measurement of nasal inflammation from October 2007 to November 2009. During the study period, daily concentrations of air pollutants were obtained from the Environmental Protection Administration monitoring station and the Aerosol Supersite. Mixed-effects models were applied to examine the association between air pollution and nasal inflammatory cells and mediators, including percentages of neutrophils, eosinophils, and monocytes in lavaged cells and interleukin-8. A total of 824 measurements were obtained from 100 participants over a period of 10 months. The level of particulate matter with an aerodynamic diameter of 2.5 μm or less (PM2.5) was found to be associated with percentage of neutrophils (β = 3.45%, 95% confidence interval: 0.89, 6.01) and interleukin-8 level (β = 29.98 pg/mL, 95% confidence interval: 3.26, 56.69) in the nasal lavage on the day of exposure. In this longitudinal cohort study of schoolchildren, results indicated that exposure to PM2.5 might induce nasal inflammation.

原文???core.languages.en_GB???
頁(從 - 到)764-774
頁數11
期刊American Journal of Epidemiology
175
發行號8
DOIs
出版狀態已出版 - 15 4月 2012

指紋

深入研究「The association of ambient air pollution with airway inflammation in schoolchildren」主題。共同形成了獨特的指紋。

引用此