The APOE e{open}4 allele affects complexity and functional connectivity of resting brain activity in healthy adults

Albert C. Yang, Chu Chung Huang, Mu En Liu, Yin Jay Liou, Chen Jee Hong, Men Tzung Lo, Norden E. Huang, Chung Kang Peng, Ching Po Lin, Shih Jen Tsai

研究成果: 雜誌貢獻期刊論文同行評審

42 引文 斯高帕斯(Scopus)

摘要

The apolipoprotein E (APOE) gene is associated with structural and functional brain changes. We have used multiscale entropy (MSE) analysis to detect changes in the complexity of resting blood oxygen level-dependent (BOLD) signals associated with aging and cognitive function. In this study, we further hypothesized that the APOE genotype may affect the complexity of spontaneous BOLD activity in younger and older adults, and such altered complexity may be associated with certain changes in functional connectivity. We conducted a resting-state functional magnetic resonance imaging experiment in a cohort of 100 younger adults (aged 20-39 years; mean 27.2±4.3 years; male/female: 53/47) and 112 older adults (aged 60-79 years; mean 68.4±6.5 years; male/female: 54/58), and applied voxelwise MSE analysis to assess the main effect of APOE genotype on resting-state BOLD complexity and connectivity. Although the main effect of APOE genotype on BOLD complexity was not observed in younger group, we observed that older APOE e{open}4 allele carriers had significant reductions in BOLD complexity in precuneus and posterior cingulate regions, relative to noncarriers. We also observed that reduced BOLD complexity in precuneus and posterior cingulate regions was associated with increased functional connectivity to the superior and inferior frontal gyrus in the older group. These results support the compensatory recruitment hypothesis in older APOE e{open}4 carriers, and confer the impact of the APOE genotype on the temporal dynamics of brain activity in older adults.

原文???core.languages.en_GB???
頁(從 - 到)3238-3248
頁數11
期刊Human Brain Mapping
35
發行號7
DOIs
出版狀態已出版 - 7月 2014

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