Tailored therapeutic decision of rheumatoid arthritis using proteomic strategies: how to start and when to stop?

Shuo Fu Chen, Fu Chiang Yeh, Ching Yun Chen, Hui Yin Chang

研究成果: 雜誌貢獻回顧評介論文同行評審

摘要

Unpredictable treatment responses have been an obstacle for the successful management of rheumatoid arthritis. Although numerous serum proteins have been proposed, there is a lack of integrative survey to compare their relevance in predicting treatment outcomes in rheumatoid arthritis. Also, little is known about their applications in various treatment stages, such as dose modification, drug switching or withdrawal. Here we present an in-depth exploration of the potential usefulness of serum proteins in clinical decision-making and unveil the spectrum of immunopathology underlying responders to different drugs. Patients with robust autoimmunity and inflammation are more responsive to biological treatments and prone to relapse during treatment de-escalation. Moreover, the concentration changes of serum proteins at the beginning of the treatments possibly assist early recognition of treatment responders. With a better understanding of the relationship between the serum proteome and treatment responses, personalized medicine in rheumatoid arthritis will be more achievable in the near future.

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文章編號22
期刊Clinical Proteomics
20
發行號1
DOIs
出版狀態已出版 - 12月 2023

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