Synthesis of Optically Active Organofluorides by Ring Opening of Oxazolidinone-Fused Aziridines

Hung Che Chen, Chi Yun Liu, Venkatachalam Angamuthu, Wei Chen Chen, Chi Sheng Wen, Duen Ren Hou

研究成果: 雜誌貢獻期刊論文同行評審

3 引文 斯高帕斯(Scopus)

摘要

A general method for synthesizing optically active, primary, secondary, and tertiary organofluorides was developed. This chiral pool synthesis utilized the skeleton of arabinose to generate diastereomerically pure 2-oxazolidinone-fused aziridines, which underwent ring opening with a fluoride anion. The adducts, polyoxygenated organofluorides, were useful precursors to various fluorinated compounds, such as fluorinated amino acids.

原文???core.languages.en_GB???
頁(從 - 到)190-194
頁數5
期刊Organic Letters
25
發行號1
DOIs
出版狀態已出版 - 13 1月 2023

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