TY - JOUR
T1 - Synthesis of membranes having a saccharide side chain and their optical resolution properties for d‐/l‐ glucose mixtures
AU - Nakagawa, Tsutomu
AU - Toyokawa, Yoshida
AU - Abe, Motoji
AU - Higuchi, Akon
PY - 1994/7
Y1 - 1994/7
N2 - The objective of the present investigation is to synthesize new polymeric membranes having a saccharide in the side chain and to clarify the specific affinity of the saccharide chains. During this study chloromethylated polysulfone (CM‐PSF), poly(chloromethylated styrene) (P‐CM‐St), poly(methyl methacrylate) (PMMA), and chlororethylated poly(γ ‐methyl L‐glutamate) (CE‐PMLG) as synthetic polymers along with an equal mixture of α‐D‐2‐deoxy‐2‐aminoglucopyranosyl‐(1'→6) ‐D‐sorbitol and mannitol (AGP) as saccharides were used. PMMA+AGP and CE‐PMLG+AGP membranes showed the highest permeability of D‐glucose in sugars (molecular weight = 180.16), although the CM‐PSP+AGP and P‐CM‐St+AGP membranes showed less permeability. The reason for the high permeability of D‐glucose is the high partition coefficient of D‐glucose, which may come from an interaction between the AGP terminating D‐glucose structure and D‐glucose as the solute. The optical resolution could be done by the difference between the D‐ and L‐glucose permeation rates from an equimolar mixture of D‐glucose and L‐glucose.
AB - The objective of the present investigation is to synthesize new polymeric membranes having a saccharide in the side chain and to clarify the specific affinity of the saccharide chains. During this study chloromethylated polysulfone (CM‐PSF), poly(chloromethylated styrene) (P‐CM‐St), poly(methyl methacrylate) (PMMA), and chlororethylated poly(γ ‐methyl L‐glutamate) (CE‐PMLG) as synthetic polymers along with an equal mixture of α‐D‐2‐deoxy‐2‐aminoglucopyranosyl‐(1'→6) ‐D‐sorbitol and mannitol (AGP) as saccharides were used. PMMA+AGP and CE‐PMLG+AGP membranes showed the highest permeability of D‐glucose in sugars (molecular weight = 180.16), although the CM‐PSP+AGP and P‐CM‐St+AGP membranes showed less permeability. The reason for the high permeability of D‐glucose is the high partition coefficient of D‐glucose, which may come from an interaction between the AGP terminating D‐glucose structure and D‐glucose as the solute. The optical resolution could be done by the difference between the D‐ and L‐glucose permeation rates from an equimolar mixture of D‐glucose and L‐glucose.
UR - http://www.scopus.com/inward/record.url?scp=84985362843&partnerID=8YFLogxK
U2 - 10.1002/masy.19940840123
DO - 10.1002/masy.19940840123
M3 - 期刊論文
AN - SCOPUS:84985362843
SN - 1022-1360
VL - 84
SP - 209
EP - 226
JO - Macromolecular Symposia
JF - Macromolecular Symposia
IS - 1
ER -