Synthesis of biocompatible TiZr-based bulk metallic glass foams for bio-implant application

V. T. Nguyen; T. H. Li; S. M. Song; Y. C. Liao; P. H. Tsai; P. C. Wong; V. C. Nguyen; J. S.C. Jang

doi:10.1016/j.matlet.2019.126650

Synthesis of biocompatible TiZr-based bulk metallic glass foams for bio-implant application

V. T. Nguyen, T. H. Li, S. M. Song, Y. C. Liao, P. H. Tsai, P. C. Wong, V. C. Nguyen, J. S.C. Jang

材料科學與工程研究所

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

12 引文斯高帕斯（Scopus）

摘要

A series of porous toxic-element-free TiZr-based bulk metallic glass foams (BMGFs) with porosities ranging from 2.0% to 38.9% were fabricated by hot-pressing method. The results indicated that the BMGFs with pore sizes of 100–300 μm exhibit relatively good mechanical properties, Young's moduli ranging from 5.8 to 56.4 GPa and compressive strength from 33 to 979 MPa which well match the properties of human bone. In in vitro tests, the TiZr-based BMGFs with porosities of 12.7% and 34.8% showed non-cytotoxicity and high extracellular calcium deposition. Owing to the excellent combination of suitable porosities, consistent mechanical properties, and high biocompatibility, the TiZr-based BMGFs are promising candidates for use in bio-implant applications from the viewpoints of avoiding stress shielding and bio-unfriendly symptoms in the human body.

原文	???core.languages.en_GB???
文章編號	126650
期刊	Materials Letters
卷	256
DOIs	https://doi.org/10.1016/j.matlet.2019.126650
出版狀態	已出版 - 1 12月 2019

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10.1016/j.matlet.2019.126650

具開放性孔隙之無毒元素添加鈦基金屬玻璃多孔材之研發(3/3)
Jang, S.-C. (PI)
1/08/18 → 31/07/19
研究計畫: Research
孔洞漸層之客製化海綿骨置換體開發-孔洞漸層之客製化海綿骨置換體開發(1/3)
Jang, S.-C. (PI)
1/09/17 → 31/07/18
研究計畫: Research

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@article{cb7565460416411aae963caac2b29316,

title = "Synthesis of biocompatible TiZr-based bulk metallic glass foams for bio-implant application",

abstract = "A series of porous toxic-element-free TiZr-based bulk metallic glass foams (BMGFs) with porosities ranging from 2.0% to 38.9% were fabricated by hot-pressing method. The results indicated that the BMGFs with pore sizes of 100–300 μm exhibit relatively good mechanical properties, Young's moduli ranging from 5.8 to 56.4 GPa and compressive strength from 33 to 979 MPa which well match the properties of human bone. In in vitro tests, the TiZr-based BMGFs with porosities of 12.7% and 34.8% showed non-cytotoxicity and high extracellular calcium deposition. Owing to the excellent combination of suitable porosities, consistent mechanical properties, and high biocompatibility, the TiZr-based BMGFs are promising candidates for use in bio-implant applications from the viewpoints of avoiding stress shielding and bio-unfriendly symptoms in the human body.",

keywords = "Amorphous materials, Biomaterials, Hot-pressing, Mechanical property, Porous materials",

author = "Nguyen, {V. T.} and Li, {T. H.} and Song, {S. M.} and Liao, {Y. C.} and Tsai, {P. H.} and Wong, {P. C.} and Nguyen, {V. C.} and Jang, {J. S.C.}",

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T1 - Synthesis of biocompatible TiZr-based bulk metallic glass foams for bio-implant application

AU - Nguyen, V. T.

AU - Li, T. H.

AU - Song, S. M.

AU - Liao, Y. C.

AU - Tsai, P. H.

AU - Wong, P. C.

AU - Nguyen, V. C.

AU - Jang, J. S.C.

PY - 2019/12/1

Y1 - 2019/12/1

N2 - A series of porous toxic-element-free TiZr-based bulk metallic glass foams (BMGFs) with porosities ranging from 2.0% to 38.9% were fabricated by hot-pressing method. The results indicated that the BMGFs with pore sizes of 100–300 μm exhibit relatively good mechanical properties, Young's moduli ranging from 5.8 to 56.4 GPa and compressive strength from 33 to 979 MPa which well match the properties of human bone. In in vitro tests, the TiZr-based BMGFs with porosities of 12.7% and 34.8% showed non-cytotoxicity and high extracellular calcium deposition. Owing to the excellent combination of suitable porosities, consistent mechanical properties, and high biocompatibility, the TiZr-based BMGFs are promising candidates for use in bio-implant applications from the viewpoints of avoiding stress shielding and bio-unfriendly symptoms in the human body.

AB - A series of porous toxic-element-free TiZr-based bulk metallic glass foams (BMGFs) with porosities ranging from 2.0% to 38.9% were fabricated by hot-pressing method. The results indicated that the BMGFs with pore sizes of 100–300 μm exhibit relatively good mechanical properties, Young's moduli ranging from 5.8 to 56.4 GPa and compressive strength from 33 to 979 MPa which well match the properties of human bone. In in vitro tests, the TiZr-based BMGFs with porosities of 12.7% and 34.8% showed non-cytotoxicity and high extracellular calcium deposition. Owing to the excellent combination of suitable porosities, consistent mechanical properties, and high biocompatibility, the TiZr-based BMGFs are promising candidates for use in bio-implant applications from the viewpoints of avoiding stress shielding and bio-unfriendly symptoms in the human body.

KW - Amorphous materials

KW - Biomaterials

KW - Hot-pressing

KW - Mechanical property

KW - Porous materials

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U2 - 10.1016/j.matlet.2019.126650

DO - 10.1016/j.matlet.2019.126650

M3 - 期刊論文

AN - SCOPUS:85071979170

SN - 0167-577X

VL - 256

JO - Materials Letters

JF - Materials Letters

M1 - 126650

ER -

Synthesis of biocompatible TiZr-based bulk metallic glass foams for bio-implant application

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具開放性孔隙之無毒元素添加鈦基金屬玻璃多孔材之研發(3/3)

孔洞漸層之客製化海綿骨置換體開發-孔洞漸層之客製化海綿骨置換體開發(1/3)

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