Synthesis of 3-Bromoindenes from 4-Alkynyl Alcohols/Sulfonamides and Aldehydes via Prins Cyclization, Ring-Opening and Friedel-Crafts Reactions

Trimurtulu Kotipalli, Duen Ren Hou

研究成果: 雜誌貢獻期刊論文同行評審

5 引文 斯高帕斯(Scopus)

摘要

A one-pot, two-staged protocol has been developed for the synthesis of 3-bromoindenes from aryl alkynyl alcohols/sulfonamides and aldehydes. Bromotrimethylsilane (TMSBr) initiated a halo-Prins cyclization reaction to give 3-(bromomethylene)-tetrahydropyrans or -piperidines, which underwent ring-opening and Friedel-Crafts allylation to yield 3-bromoindenes in the presence of Brønsted acids.

原文???core.languages.en_GB???
頁(從 - 到)1561-1571
頁數11
期刊Asian Journal of Organic Chemistry
8
發行號8
DOIs
出版狀態已出版 - 8月 2019

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