摘要
A series of new conjugated compounds with a-SCH2-linkage were synthesized by chemical methods from imidazole and coumarin derivatives. The experimental results indicate that of the twenty newly synthesized imidazole-coumarin conjugates, three of them exhibited appealing EC50 values (5.1-8.4 μM) and selective indices >20 against hepatitis C virus. Their potency and selectivity were increased substantially by modification of their structure with two factors: imidazole nucleus with a hydrogen atom at the N(1) position and coumarin nucleus with a substituent, such as Cl, F, Br, Me, and OMe. These guidelines provide valuable information for further development of conjugated compounds as anti-viral agents.
原文 | ???core.languages.en_GB??? |
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文章編號 | 228 |
期刊 | Molecules |
卷 | 21 |
發行號 | 2 |
DOIs | |
出版狀態 | 已出版 - 2月 2016 |