Syntheses of acyclic analogs of didemnin B

Joshi M. Ramanjulu; Madeleine M. Joullié; Wen Ren Li

doi:10.1080/00397919708004186

Syntheses of acyclic analogs of didemnin B

Joshi M. Ramanjulu, Madeleine M. Joullié, Wen Ren Li

化學學系

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

2 引文斯高帕斯（Scopus）

摘要

The syntheses of three modified peptide fragments of the cyclodepsipeptide didemnin B are reported. The HIP and isostatine (Ist) units of the didemnin B macrocycle were simplified to a Z-alanine residue and the ester linkage (through threonine of the tetrapeptide) was replaced with amide linkages through the amines of glycine. D-alanine and an ethylenediamine linker. The latter permitted the attachment of a N-Me-D-Leu-Pro-Lac moiety to afford analogs 2, 3 and 4 respectively.

原文	???core.languages.en_GB???
頁（從 - 到）	3259-3272
頁數	14
期刊	Synthetic Communications
卷	27
發行號	18
DOIs	https://doi.org/10.1080/00397919708004186
出版狀態	已出版 - 1997

存取文件

10.1080/00397919708004186

引用此

@article{07a74a09243743ea86ab5f70000a7330,

title = "Syntheses of acyclic analogs of didemnin B",

abstract = "The syntheses of three modified peptide fragments of the cyclodepsipeptide didemnin B are reported. The HIP and isostatine (Ist) units of the didemnin B macrocycle were simplified to a Z-alanine residue and the ester linkage (through threonine of the tetrapeptide) was replaced with amide linkages through the amines of glycine. D-alanine and an ethylenediamine linker. The latter permitted the attachment of a N-Me-D-Leu-Pro-Lac moiety to afford analogs 2, 3 and 4 respectively.",

author = "Ramanjulu, {Joshi M.} and Joulli{\'e}, {Madeleine M.} and Li, {Wen Ren}",

note = "Funding Information: Acknowledgments. Financial support by the National Institutes of Health (CA-40081)",

year = "1997",

doi = "10.1080/00397919708004186",

language = "???core.languages.en_GB???",

volume = "27",

pages = "3259--3272",

journal = "Synthetic Communications",

issn = "0039-7911",

number = "18",

}

TY - JOUR

T1 - Syntheses of acyclic analogs of didemnin B

AU - Ramanjulu, Joshi M.

AU - Joullié, Madeleine M.

AU - Li, Wen Ren

N1 - Funding Information: Acknowledgments. Financial support by the National Institutes of Health (CA-40081)

PY - 1997

Y1 - 1997

N2 - The syntheses of three modified peptide fragments of the cyclodepsipeptide didemnin B are reported. The HIP and isostatine (Ist) units of the didemnin B macrocycle were simplified to a Z-alanine residue and the ester linkage (through threonine of the tetrapeptide) was replaced with amide linkages through the amines of glycine. D-alanine and an ethylenediamine linker. The latter permitted the attachment of a N-Me-D-Leu-Pro-Lac moiety to afford analogs 2, 3 and 4 respectively.

AB - The syntheses of three modified peptide fragments of the cyclodepsipeptide didemnin B are reported. The HIP and isostatine (Ist) units of the didemnin B macrocycle were simplified to a Z-alanine residue and the ester linkage (through threonine of the tetrapeptide) was replaced with amide linkages through the amines of glycine. D-alanine and an ethylenediamine linker. The latter permitted the attachment of a N-Me-D-Leu-Pro-Lac moiety to afford analogs 2, 3 and 4 respectively.

UR - http://www.scopus.com/inward/record.url?scp=0030747640&partnerID=8YFLogxK

U2 - 10.1080/00397919708004186

DO - 10.1080/00397919708004186

M3 - 期刊論文

AN - SCOPUS:0030747640

VL - 27

SP - 3259

EP - 3272

JO - Synthetic Communications

JF - Synthetic Communications

SN - 0039-7911

IS - 18

ER -

Syntheses of acyclic analogs of didemnin B

摘要

存取文件

指紋

引用此