Suppression of cardiac alternans by alternating-period-feedback stimulations

S. Sridhar, Duy Manh Le, Yun Chieh Mi, Sitabhra Sinha, Pik Yin Lai, C. K. Chan

研究成果: 雜誌貢獻期刊論文同行評審

15 引文 斯高帕斯(Scopus)


Alternans response, comprising a sequence of alternating long and short action potential durations in heart tissue, seen during rapid periodic pacing can lead to conduction block resulting in potentially fatal cardiac failure. A method of pacing with feedback control is proposed to reduce the alternans and therefore the probability of subsequent cardiac failure. The reduction is achieved by feedback control using small perturbations of constant magnitude to the original, alternans-generating pacing period T, viz., using sequences of two alternating periods of T+ΔT and T-ΔT, with ΔTT. Such a control scheme for alternans suppression is demonstrated experimentally in isolated whole heart experiments. This alternans suppression scheme is further confirmed and investigated in detail by simulations of ion-channel-based cardiac models both for a single cell and in one-dimensional spatially extended systems. The mechanism of the success of our method can be understood in terms of dynamics in phase space, viz., as the state of activity of the cell being confined within a narrow volume of phase space for the duration of control, resulting in extremely diminished variation in successive action potential durations. Our method is much more robust to noise than previous alternans reduction techniques based on fixed point stabilization and should thus be more efficient in terms of experimental implementation, which has implications for clinical treatment for arrhythmia.

期刊Physical Review E - Statistical, Nonlinear, and Soft Matter Physics
出版狀態已出版 - 15 4月 2013


深入研究「Suppression of cardiac alternans by alternating-period-feedback stimulations」主題。共同形成了獨特的指紋。