Sulfur-containing natural zwitterionic amino acids and derivative on gold: Study on physicochemical and anti-fouling properties

Sz Hau Chu, Chia Yu Liu, Ying Chih Chang, Chun Jen Huang

研究成果: 書貢獻/報告類型會議論文篇章同行評審

摘要

Many researchers have found that the stability of SAMs is an issue for long-term biomedical applications. The surface functional group is not stable under ambient conditions. To address this problem, we use cysteine, natural sulfurcontaining zwitterionic compounds, and cysteine betaine which is the derivative of cycteine, with quaternary ammonium group at its terminal end, to decorate Au substrate by using the chemisorbing properties of the thiol group. By adding various different additives into the solution of alkanethiols during SAM formation to eliminate unbound thiol and to prevent the degradation processes of alkanethiol SAMs, we can decrease the film thickness and increase the wettability. Furthermore, we also compared their physical and chemical properties of amino acids SAMs on Au that were stored under different conditions for various lengths of time. Based on the above, our study aims to investigate the influence of different SAMs condition and chemical structure for anti-fouling properties. Contact angle analysis indicated that after degradation, the photooxidation sample decreased relative to that of the freshly prepared SAMs. X-ray photoelectron spectroscopy (XPS) not only used to detect the chemical elements of SAMs on Au substrates, but also detect the changes in the chemical state of the surface oxidized atoms. The bacterial adhesion tests revealed the excellent anti-fouling properties of zwitterionic amino acids SAMs. And adopt MTT assay to assessing cell viability.

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主出版物標題1st Global Conference on Biomedical Engineering and 9th Asian-Pacific Conference on Medical and Biological Engineering
編輯Fong-Chin Su, Ming-Long Yeh, Shyh-Hau Wang
發行者Springer Verlag
頁面21-23
頁數3
ISBN(電子)9783319122618
DOIs
出版狀態已出版 - 2015
事件1st Global Conference on Biomedical Engineering, GCBME 2014 and 9th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2014 - Tainan, Taiwan
持續時間: 9 10月 201412 10月 2014

出版系列

名字IFMBE Proceedings
47
ISSN(列印)1680-0737
ISSN(電子)1433-9277

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???event.eventtypes.event.conference???1st Global Conference on Biomedical Engineering, GCBME 2014 and 9th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2014
國家/地區Taiwan
城市Tainan
期間9/10/1412/10/14

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