Study design for a three-arm equivalence clinical trial with binomially distributed outcomes

Keyphrases

• Clinical Trials 100%
• Placebo 100%
• Hypothesis Testing 66%
• Maximum Likelihood Estimation 66%
• Power Function 66%
• Required Sample Size 66%
• Equivalence Trial 66%
• Proposed Design 33%
• Test Statistic 33%
• Function-based 33%
• Three-arm Trial 33%
• Restricted Maximum Likelihood 33%
• Drug Reference 33%
• Desired Power 33%

Mathematics

• Minimizes 100%
• Hypothesis Test 100%
• Power Function 100%
• Maximum Likelihood Estimate 100%
• Test Statistic 50%
• Superiority 50%
• significance level α 50%
• Arm Trial 50%
• Desired Power 50%

Medicine and Dentistry

• Clinical Trial 100%
• Arm 100%
• Placebo 60%
• Maximum Likelihood Method 40%