Studies of drug delivery and drug release of dendrimer by dissipative particle dynamics

Chun Min Lin, Yi Fan Wu, Heng Kwong Tsao, Yu Jane Sheng

研究成果: 書貢獻/報告類型會議論文篇章同行評審

1 引文 斯高帕斯(Scopus)

摘要

Dendrimers, like unimolecular micelles, may encapsulate guest biomolecules (drug) and therefore are attractive candidates as carriers in drug delivery applications. Hydrophobic drugs can be complexed within the hydrophobic dendrimer interior to make them water-soluble. The equilibrium partition of hydrophobic solutes into a dendrimer with hydrophobic interior from aqueous solutions is studied by dissipative particle dynamics. The drug is mainly distributed in the vicinity of the interface between hydrophobic interior and hydrophilic exterior within a dendrimer. The partition coefficient, which is defined as the concentration ratio of the drug distributed within dendrimer to aqueous phases, depends on the interaction between drug and hydrophilic dendrimer exterior. Increasing the repulsion between them reduces the solubilization ability associated with the dendrimer.

原文???core.languages.en_GB???
主出版物標題Complex Systems - 5th International Workshop on Complex Systems
頁面525-527
頁數3
DOIs
出版狀態已出版 - 2008
事件5th International Workshop on Complex Systems - Sendai, Japan
持續時間: 25 9月 200728 9月 2007

出版系列

名字AIP Conference Proceedings
982
ISSN(列印)0094-243X
ISSN(電子)1551-7616

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???event.eventtypes.event.conference???5th International Workshop on Complex Systems
國家/地區Japan
城市Sendai
期間25/09/0728/09/07

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