Strong repulsive forces between protein and oligo (ethylene glycol) self-assembled monolayers: A molecular simulation study

Jie Zheng, Lingyan Li, Heng Kwong Tsao, Yu Jane Sheng, Shenfu Chen, Shaoyi Jiang

研究成果: 雜誌貢獻期刊論文同行評審

324 引文 斯高帕斯(Scopus)

摘要

Restrained molecular dynamics simulations were performed to study the interaction forces of a protein with the self-assembled monolayers (SAMs) of S(CH2)4(EG)4OH, S(CH2) 11OH, and S(CH2)11CH3 in the presence of water molecules. The force-distance curves were calculated by fixing the center of mass of the protein at several separation distances from the SAM surface. Simulation results show that the relative strength of repulsive force acting on the protein is in the decreasing order of OEG-SAMs > OH-SAMs > CH3-SAMs. The force contributions from SAMs and water molecules, the structural and dynamic behavior of hydration water, and the flexibility and conformation state of SAMs were also examined to study how water structure at the interface and SAM flexibility affect the forces exerted on the protein. Results show that a tightly bound water layer adjacent to the OEG-SAMs is mainly responsible for the large repulsive hydration force.

原文???core.languages.en_GB???
頁(從 - 到)158-166
頁數9
期刊Biophysical Journal
89
發行號1
DOIs
出版狀態已出版 - 7月 2005

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