Stratum corneum lipid structure: Insights from NMR and FTIR spectroscopic studies

Ya Wei Hsueh, Jenifer Thewalt, Neil Kitson, David J. Moore

研究成果: 書貢獻/報告類型篇章同行評審

1 引文 斯高帕斯(Scopus)


The lipid matrix of the stratum corneum (SC) provides several critical physiological functions, the most important of which is protecting the body from dehydration. In recent years our knowledge of lipid composition in the stratum corneum, and of the enzymatic pathways by which these lipids are generated, has increased significantly. It is now well established, for example, that the SC lipid matrix consists primarily of saturated free fatty acids, cholesterol, and arange of ceramide species but does not appear to contain any phospholipids or significant amounts of unsaturated lipids [1]. As discussed elsewhere, many elegant X-ray and electron microscopy studies have yielded a picture of the stratum corneum lipid matrix in which these extracellular lipid components can be seen to consist of stacked lamellae, within which are embedded the corneocytes of the SC. It is obvious that full comprehension of SC barrier physiology necessitates a detailed, understanding of lateral and transverse lipid organization at the molecular level. However, a detailed description of molecular organization, and the specific structural and functional role of lipid heterogeneity in the SC, remain to be experimentally determined.

主出版物標題Skin, Hair, and Nails
主出版物子標題Structure and Function
發行者CRC Press
出版狀態已出版 - 1 1月 2003


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