Static craniofacial measurements and dynamic airway collapse patterns associated with severe obstructive sleep apnoea: a sleep MRI study

Stanley Yung Chuan Liu, Leh Kiong Huon, Men Tzung Lo, Yi Chung Chang, Robson Capasso, Yunn Jy Chen, Tiffany Ting Fang Shih, Pa Chun Wang

研究成果: 雜誌貢獻期刊論文同行評審

23 引文 斯高帕斯(Scopus)

摘要

Objectives: Using sleep MRI, we aimed to identify static craniofacial measurements and dynamic upper airway collapse patterns associated with severe obstructive sleep apnoea (OSA) during natural sleep in age and BMI-matched patients. Design: Nested case–control study. Setting: Sleep MRI images (3.0 Tesla scanner) and synchronised acoustic recording were used to observe patterns of dynamic airway collapse in subjects with mild and severe OSA. Midsagittal images were also used for static craniofacial measurements. Participants: Fifteen male subjects with severe OSA (mean AHI 70.3 ± 23 events/h) were matched by age and BMI to 15 subjects with mild OSA (mean AHI 7.8 ± 1.4 events/h). Subjects were selected from a consecutive sleep MRI study cohort. Main outcome measures: Static craniofacial measurements selected a priori included measurements that represent maxillomandibular relationships and airway morphology. Axial, sagittal and coronal views of the airway were rated for dynamic collapse at retropalatal, retroglossal and lateral pharyngeal wall regions by blinded reviewers. Bivariate analysis was used to correlate measures associated with severity of OSA using AHI. Statistical significance was set at P < 0.01. Results: Lateral pharyngeal wall collapse from dynamic sleep MRI (β = 51.8, P < 0.001) and upper airway length from static MRI images (β = 27.2, P < 0.001) positively correlated with severity of OSA. Conclusions: Lateral pharyngeal wall collapse and upper airway length are significantly associated with severe OSA based on sleep MRI. Assessment of these markers can be readily translated to routine clinical practice, and their identification may direct targeted surgical treatment.

原文???core.languages.en_GB???
頁(從 - 到)700-706
頁數7
期刊Clinical Otolaryngology
41
發行號6
DOIs
出版狀態已出版 - 1 12月 2016

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