摘要
Solubility, polymorphism, crystallinity, and crystal habit of acetaminophen and racemic (±)-ibuprofen were determined by initial screening of 23 solvents for scale-up. Solubility curves were constructed, and solubility at 25 °C was plotted against the dielectric constants of various solvent as a fingerprint for solute identification. The total "form space" for acetaminophen and racemic (±)-ibuprofen were calculated to be 222 and 257, respectively. Various crystal habits and sizes for ibuprofen and acetaminophen were observed.
| 原文 | ???core.languages.en_GB??? |
|---|---|
| 頁（從 - 到） | 72-92 |
| 頁數 | 21 |
| 期刊 | Pharmaceutical Technology |
| 卷 | 30 |
| 發行號 | 10 |
| 出版狀態 | 已出版 - 10月 2006 |