Solubility, polymorphism, crystallinity, and crystal habit of acetaminophen and ibuprofen: By initial solvent screening

Tu Lee, Chung Shin Kuo, Yino Hsiu Chen

研究成果: 雜誌貢獻回顧評介論文同行評審

68 引文 斯高帕斯(Scopus)

摘要

Solubility, polymorphism, crystallinity, and crystal habit of acetaminophen and racemic (±)-ibuprofen were determined by initial screening of 23 solvents for scale-up. Solubility curves were constructed, and solubility at 25 °C was plotted against the dielectric constants of various solvent as a fingerprint for solute identification. The total "form space" for acetaminophen and racemic (±)-ibuprofen were calculated to be 222 and 257, respectively. Various crystal habits and sizes for ibuprofen and acetaminophen were observed.

原文???core.languages.en_GB???
頁(從 - 到)72-92
頁數21
期刊Pharmaceutical Technology
30
發行號10
出版狀態已出版 - 10月 2006

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