Solid-phase synthesis of isoquinolinones using Bischler-Napieralski cyclization

Meei Shiou Chern, Wen Ren Li

研究成果: 雜誌貢獻期刊論文同行評審

33 引文 斯高帕斯(Scopus)

摘要

A traceless solid-phase synthetic approach to isoquinolinones is described here. This approach allows introducing both electron-donating as well as electron-withdrawing moieties on the benzene nuclei of isoquinolinones with high yields and purities. Isoquinolinone is a structural unit found in many natural products having various important biological activities. A traceless solid-phase synthetic approach has been developed to prepare isoquinolinone derivatives. This approach enables one to synthesize isoquinolinones having various moieties on benzene nuclei and also can produce derivatives with a proton on the amide nitrogen.

原文???core.languages.en_GB???
頁(從 - 到)8323-8326
頁數4
期刊Tetrahedron Letters
45
發行號45
DOIs
出版狀態已出版 - 1 11月 2004

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