Silanization of Silicone Elastomer with Zwitterionic Surface Modifier for Robust Biocompatibility

Shiou Bang Yeh, Chien Sheng Chen, Wen Yih Chen, Chia Yu Liu, Chun Jen Huang

研究成果: 書貢獻/報告類型會議論文篇章同行評審

1 引文 斯高帕斯(Scopus)

摘要

Biofouling generally causes adverse effects to health, such as thrombosis, infection, and pathogenic calcification. Hydrophilic and charge-balanced surface is proved to provide an energy barrier serving as a strong repulsive force against the nonspecific absorption. Unfortunately, the state-ofart technology for silicone modification cannot provide a stable and effective coating for the long-term applications under complex conditions. In this study, we aim to modify the silicone surfaces with a zwitterionic surface ligand to resist nonspecific adsorption of protein, lipid and bacteria. We synthesized a silanized surface ligand conjugated with a head residue of zwitterionic sulfobetaine (SBSi) that bears positively charged quaternary amine and negatively charged sulfonate groups. The bacterial adhesion tests and protein fouling test revealed the excellent antifouling properties of modified silicones. For the real-world application, we modified commercially available silicone hydrogel contact lenses with developed zwitterionic ligands and showed their capability of anti-bacterial adhesion and anti protein fouling. In summary, the strategy of surface engineering in this work can be applied to not only contact lenses but other silicone-based medical devices in facile and effective fashion.

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主出版物標題1st Global Conference on Biomedical Engineering and 9th Asian-Pacific Conference on Medical and Biological Engineering
編輯Shyh-Hau Wang, Fong-Chin Su, Ming-Long Yeh
發行者Springer Verlag
頁面1-4
頁數4
ISBN(電子)9783319122618
DOIs
出版狀態已出版 - 2015
事件1st Global Conference on Biomedical Engineering, GCBME 2014 and 9th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2014 - Tainan, Taiwan
持續時間: 9 10月 201412 10月 2014

出版系列

名字IFMBE Proceedings
47
ISSN(列印)1680-0737

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???event.eventtypes.event.conference???1st Global Conference on Biomedical Engineering, GCBME 2014 and 9th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2014
國家/地區Taiwan
城市Tainan
期間9/10/1412/10/14

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