@inproceedings{d1d5b6fd16f44972aad70658d5857604,
title = "Silanization of Silicone Elastomer with Zwitterionic Surface Modifier for Robust Biocompatibility",
abstract = "Biofouling generally causes adverse effects to health, such as thrombosis, infection, and pathogenic calcification. Hydrophilic and charge-balanced surface is proved to provide an energy barrier serving as a strong repulsive force against the nonspecific absorption. Unfortunately, the state-ofart technology for silicone modification cannot provide a stable and effective coating for the long-term applications under complex conditions. In this study, we aim to modify the silicone surfaces with a zwitterionic surface ligand to resist nonspecific adsorption of protein, lipid and bacteria. We synthesized a silanized surface ligand conjugated with a head residue of zwitterionic sulfobetaine (SBSi) that bears positively charged quaternary amine and negatively charged sulfonate groups. The bacterial adhesion tests and protein fouling test revealed the excellent antifouling properties of modified silicones. For the real-world application, we modified commercially available silicone hydrogel contact lenses with developed zwitterionic ligands and showed their capability of anti-bacterial adhesion and anti protein fouling. In summary, the strategy of surface engineering in this work can be applied to not only contact lenses but other silicone-based medical devices in facile and effective fashion.",
keywords = "Anti-fouling, Biocompatibility, Contact lenses, Zwitterionic materials",
author = "Yeh, {Shiou Bang} and Chen, {Chien Sheng} and Chen, {Wen Yih} and Liu, {Chia Yu} and Huang, {Chun Jen}",
note = "Publisher Copyright: {\textcopyright} Springer International Publishing Switzerland 2015.; 1st Global Conference on Biomedical Engineering, GCBME 2014 and 9th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2014 ; Conference date: 09-10-2014 Through 12-10-2014",
year = "2015",
doi = "10.1007/978-3-319-11128-5_1",
language = "???core.languages.en_GB???",
series = "IFMBE Proceedings",
publisher = "Springer Verlag",
pages = "1--4",
editor = "Shyh-Hau Wang and Fong-Chin Su and Ming-Long Yeh",
booktitle = "1st Global Conference on Biomedical Engineering and 9th Asian-Pacific Conference on Medical and Biological Engineering",
}