Following the 1999 Mw 7.6 Chi-Chi earthquake, a large amount of seismicity occurred in the Nantou region of central Taiwan. Among the seismic activities, eight Mw≥5.8 earthquakes took place following the Chi-Chi earthquake, whereas only four earthquakes with comparable magnitudes took place from 1900 to 1998. Since the seismicity rate during the Chi-Chi postseismic period has never returned to the background level, such seismicity activation cannot simply be attributed to modified Omori's Law decay. In this work, we attempted to associate seismic activities with stress evolution. Based on our work, it appears that the spatial distribution of the consequent seismicity can be associated with increasing coseismic stress. On the contrary, the stress changes imparted by the afterslip; lower crust-upper mantle viscoelastic relaxation; and sequent events resulted in a stress drop in most of the study region. Understanding seismogenic mechanisms in terms of stress evolution would be beneficial to seismic hazard mitigation.