Resonance-enhanced functional third harmonic optical microscopy

Shi Wei Chu, Szu Yu Chen, Tsung Han Tsai, Tzu Ming Liu, Shr Bin Wu, Sajal Biring, Juen Kai Wang, Yu Lin Wang, Kevin Chen, Bai Lin Lin, C. K. Sun

研究成果: 雜誌貢獻會議論文同行評審


For the purpose of functional third harmonic optical microscopy, it is necessary to find a method to locally enhance third harmonic generation at specific cellular site. We have demonstrated that by matching the third harmonic generation frequency of a Cr:forsterite laser and the surface plasmon resonance frequency of <50-nm silver nanoparticles, localized enhancement of third harmonic intensity of more than 100-folds can be achieved both in phantom and in real biological tissues. This strongly enhanced third harmonic signal can then be applied to specific molecule imaging by attaching the nanoparticles to the target molecule with the advantages of noninvasiveness and deep penetration capability.

頁(從 - 到)306-313
期刊Proceedings of SPIE - The International Society for Optical Engineering
出版狀態已出版 - 2004
事件Progress in Biomedical Optics and Imaging - Multiphoton Microscopy in the Biomedical Sciences IV - San Jose, CA, United States
持續時間: 25 1月 200427 1月 2004


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