Recycling of resolving agent and solvent by water-based reactions and phase diagrams: Chiral resolution study of racemic ibuprofen

Keyphrases

• Water-based 100%
• Phase Diagram 100%
• Resolution Studies 100%
• Racemic Ibuprofen 100%
• Resolving Agent 100%
• Chiral Resolution 100%
• Diastereomeric Salt 62%
• Racemate 37%
• Mother Liquor 37%
• Slurry 25%
• Reactive Crystallization 25%
• Solvent Medium 25%
• Solute 12%
• Filtrate 12%
• Acid-base 12%
• E-factor 12%
• Achiral 12%
• Recrystallization 12%
• Chemical Processing 12%
• Phenylethylamine 12%
• Solid-solid Conversion 12%
• Closed-loop Recycling 12%

Chemistry

• Chirality in Separations 100%
• Phase Diagrams 100%
• Ibuprofen 100%
• Diastereomer 83%
• Racemate 50%
• Table Salt 50%
• Base 16%
• Solubilizing 16%
• 1-Phenylethylamine 16%

Pharmacology, Toxicology and Pharmaceutical Science

• Ibuprofen 100%
• Table Salt 50%
• Crystallization 33%
• Base 16%
• Alpha Methylbenzylamine 16%