TY - JOUR
T1 - Recyclable positive azeotropes for the purification of curcumin with optimum purity and solvent capacity
AU - Tseng, Jia De
AU - Lee, Hung Lin
AU - Yeh, Kuan Lin
AU - Lee, Tu
N1 - Publisher Copyright:
© 2022 Institution of Chemical Engineers
PY - 2022/4
Y1 - 2022/4
N2 - Purification of curcumin (CUR) from crude CUR, which is referred to as curcuminoids, has been conducted by cooling crystallization with the use of two azeotropes of ethyl acetate/ethanol (AZE-EA/EtOH) and ethyl acetate/isopropyl alcohol (AZE-EA/IPA), as compared to the use of single solvents, including acetone, EA, EtOH, and IPA. According to the determination of crude CUR solubility in those solvents, the effects of stirring, crystallization time, and seeding on the induction time, purity, and yield of CUR product were investigated on a small scale. Especially the effects of the purity of CUR seed crystals have a positive trend on the CUR purity. Seeding at a high temperature is suggested. The use of AZE-EA/EtOH shows the optimum purity of 94.0% and solvent capacity of 16.0 mg/mL with a yield of 29.0% by seeded cooling crystallization in a single step. Similar results are observed in the larger scale purification of CUR with a higher purity of 94.9%. After purification, the azeotropes can easily be recovered for reuse without changing their compositions, confirmed by GC, density, and boiling point determination.
AB - Purification of curcumin (CUR) from crude CUR, which is referred to as curcuminoids, has been conducted by cooling crystallization with the use of two azeotropes of ethyl acetate/ethanol (AZE-EA/EtOH) and ethyl acetate/isopropyl alcohol (AZE-EA/IPA), as compared to the use of single solvents, including acetone, EA, EtOH, and IPA. According to the determination of crude CUR solubility in those solvents, the effects of stirring, crystallization time, and seeding on the induction time, purity, and yield of CUR product were investigated on a small scale. Especially the effects of the purity of CUR seed crystals have a positive trend on the CUR purity. Seeding at a high temperature is suggested. The use of AZE-EA/EtOH shows the optimum purity of 94.0% and solvent capacity of 16.0 mg/mL with a yield of 29.0% by seeded cooling crystallization in a single step. Similar results are observed in the larger scale purification of CUR with a higher purity of 94.9%. After purification, the azeotropes can easily be recovered for reuse without changing their compositions, confirmed by GC, density, and boiling point determination.
KW - Cooling crystallization
KW - Curcuminoids
KW - Seeding
UR - http://www.scopus.com/inward/record.url?scp=85125235465&partnerID=8YFLogxK
U2 - 10.1016/j.cherd.2022.02.019
DO - 10.1016/j.cherd.2022.02.019
M3 - 期刊論文
AN - SCOPUS:85125235465
SN - 0263-8762
VL - 180
SP - 200
EP - 211
JO - Chemical Engineering Research and Design
JF - Chemical Engineering Research and Design
ER -