TY - JOUR
T1 - Recovery of Active Pharmaceutical Ingredients from Unused Solid Dosage-Form Drugs
AU - Pratama, Dhanang Edy
AU - Hsieh, Wen Chen
AU - Elmaamoun, Ahmed
AU - Lee, Hung Lin
AU - Lee, Tu
N1 - Publisher Copyright:
© 2020 American Chemical Society. All rights reserved.
PY - 2020/11/17
Y1 - 2020/11/17
N2 - The concept of drug recycle by recovering active pharmaceutical ingredients (APIs) from unused tablets and capsules was demonstrated using acetaminophen, tetracycline HCl, and (R,S)-(±)-ibuprofen as case examples. The recovery process comprised three core unit operations: solid-liquid extraction, filtration, and crystallization. Recovery yields of 58.7 wt %, 73.1 wt %, and 67.6 wt % for acetaminophen, tetracycline HCl, and (R,S)-(±)-ibuprofen were achieved, respectively. More importantly, all of the APIs were of high purity based on high-performance liquid chromatography assay. The crystal forms of the recovered APIs were in conformity with the standards.
AB - The concept of drug recycle by recovering active pharmaceutical ingredients (APIs) from unused tablets and capsules was demonstrated using acetaminophen, tetracycline HCl, and (R,S)-(±)-ibuprofen as case examples. The recovery process comprised three core unit operations: solid-liquid extraction, filtration, and crystallization. Recovery yields of 58.7 wt %, 73.1 wt %, and 67.6 wt % for acetaminophen, tetracycline HCl, and (R,S)-(±)-ibuprofen were achieved, respectively. More importantly, all of the APIs were of high purity based on high-performance liquid chromatography assay. The crystal forms of the recovered APIs were in conformity with the standards.
UR - http://www.scopus.com/inward/record.url?scp=85097051309&partnerID=8YFLogxK
U2 - 10.1021/acsomega.0c03878
DO - 10.1021/acsomega.0c03878
M3 - 期刊論文
AN - SCOPUS:85097051309
SN - 2470-1343
VL - 5
SP - 29147
EP - 29157
JO - ACS Omega
JF - ACS Omega
IS - 45
ER -