Recent development in nano-sized dosage forms of plant alkaloid camptothecin-derived drugs

Nguyen Van Cuong, Ming Fa Hsieh, Chun Ming Huang

研究成果: 雜誌貢獻回顧評介論文同行評審

10 引文 斯高帕斯(Scopus)

摘要

DNA topoisomerase is one of drug targets in cancer therapy. Camptothecin is a plant alkaloid derived from the Chinese tree Camptotheca acuminate. It has been demonstrated that the plant alkaloid camptothecin (CPT) caused DNA damage by specifically targeting DNA topoisomerase, effectively devastating a broad spectrum of tumors. Although the anti-tumoral activity of CPT has been intensively studies for nearly fifty years, recent advances in drug delivery systems of CPT have considerably improved this drug's efficiency. In this review, we will summarize the current status of CPT-derived anti-cancer drugs in literatures and patents and highlight their clinical application.

原文???core.languages.en_GB???
頁(從 - 到)254-261
頁數8
期刊Recent Patents on Anti-Cancer Drug Discovery
4
發行號3
DOIs
出版狀態已出版 - 2009

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