Reaction Rates for the Production of Polyphenylalanine and Polyserine by Solid Phase Peptide Synthesis with Low Excesses of the Symmetrical Anhydride

Wen‐Yih ‐Y Chen, Gary L. Foutch

研究成果: 雜誌貢獻期刊論文同行評審

3 引文 斯高帕斯(Scopus)

摘要

Continuous monitoring with UV‐absorbance was used to obtain coupling reaction rates between t‐Boc amino symmetrical anhydrides and the amino terminus of the peptide by solid phase synthesis. A kinetic model was established for the synthesis of polyserine and polyphenylalanine with rate constants determined over selected reaction temperatures, mixing rates, peptide chain lengths, and excess mole ratios of t‐Boc amino acid.

原文???core.languages.en_GB???
頁(從 - 到)51-56
頁數6
期刊Biotechnology Progress
5
發行號2
DOIs
出版狀態已出版 - 6月 1989

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