Quantifying brain atrophy of Multiple System Atrophy of the Cerebellar type (MSA-C) using fractal dimension analysis

Z. Y. Wang, B. W. Soong, P. S. Wang, C. W. Jao, K. K. Shyu, Y. T. Wu

研究成果: 書貢獻/報告類型會議論文篇章同行評審

摘要

Multiple system atrophy-cerebellar (MSA-C) is a degenerative neurological disease of brain. In this study, we used three-dimensional (3D) fractal dimension (FD) method to investigate the structural complexity change of human cerebellum white matter (CBWM) and gray matter (CBGM) for MSA-C disease diagnosis. The original T-1 weighted magnetic resonance (MR) images of twenty-three MSA-C patients and twenty-one normal subjects were processed and the 3D CBGM and 3D CBGM were quantitatively analysed by the FD method. Results showed that FD values of the CBWM and CBGM of the MSA-C patients were significantly smaller comparing with the control group. Furthermore, the results of this study also demonstrated that the FD method is superior to the conventionally volumetric method in terms of better accuracy and sensitivity. The use of FD analysis in conjunction with the conventionally volumetric methods further allows us to establish a separating line in the FD-volume scatter plot of CBWM to identify the occurrence of cerebellum atrophy, which can serve as an early-stage indicator for detecting the MSA-C disease.

原文???core.languages.en_GB???
主出版物標題World Congress on Medical Physics and Biomedical Engineering
主出版物子標題Diagnostic Imaging
發行者Springer Verlag
頁面940-943
頁數4
版本2
ISBN(列印)9783642038785
DOIs
出版狀態已出版 - 2009
事件World Congress on Medical Physics and Biomedical Engineering: Diagnostic Imaging - Munich, Germany
持續時間: 7 9月 200912 9月 2009

出版系列

名字IFMBE Proceedings
號碼2
25
ISSN(列印)1680-0737

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???event.eventtypes.event.conference???World Congress on Medical Physics and Biomedical Engineering: Diagnostic Imaging
國家/地區Germany
城市Munich
期間7/09/0912/09/09

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