@article{b7c3abd9ab274c6181b674d886ed6337,
title = "Proteomics reveals that proteins expressed during the early stage of Bacillus anthracis infection are potential targets for the development of vaccines and drugs.",
abstract = "In this review, we advance a new concept in developing vaccines and/or drugs to target specific proteins expressed during the early stage of Bacillus anthracis (anthrax) infection and address existing challenges to this concept. Three proteins (immune inhibitor A, GPR-like spore protease, and alanine racemase) initially identified by proteomics in our laboratory were found to have differential expressions during anthrax spore germination and early outgrowth. Other studies of different bacillus strains indicate that these three proteins are involved in either germination or cytotoxicity of spores, suggesting that they may serve as potential targets for the design of anti-anthrax vaccines and drugs.",
author = "Huang, {Chun Ming} and Elmets, {Craig A.} and Tang, {De chu C.} and Fuming Li and Nabiha Yusuf",
note = "Funding Information: This work was supported by National Institutes of Health Grants ( 1-R21-AI58002-01 , R01-CA79820 , R01-AI50150 , P30-AR050948 , 1-R43-AI-47558-01A2 and R01 CA86172-01 ), a Dermatology Foundation Grant, a VA Grant 18-103-02 , an Office of Naval Research Grant N00014-01-1-0945 , a Department of Defense Grant APN 07363 , a SERCEB grant 5 U54 AI057157-02 , and the UAB Comprehensive Cancer Center of USA.",
year = "2004",
month = aug,
doi = "10.1016/S1672-0229(04)02020-0",
language = "???core.languages.en_GB???",
volume = "2",
pages = "143--151",
journal = "Genomics, proteomics & bioinformatics / Beijing Genomics Institute",
issn = "1672-0229",
number = "3",
}