Proteomics reveals that proteins expressed during the early stage of Bacillus anthracis infection are potential targets for the development of vaccines and drugs.

Chun Ming Huang, Craig A. Elmets, De chu C. Tang, Fuming Li, Nabiha Yusuf

研究成果: 雜誌貢獻回顧評介論文同行評審

32 引文 斯高帕斯(Scopus)

摘要

In this review, we advance a new concept in developing vaccines and/or drugs to target specific proteins expressed during the early stage of Bacillus anthracis (anthrax) infection and address existing challenges to this concept. Three proteins (immune inhibitor A, GPR-like spore protease, and alanine racemase) initially identified by proteomics in our laboratory were found to have differential expressions during anthrax spore germination and early outgrowth. Other studies of different bacillus strains indicate that these three proteins are involved in either germination or cytotoxicity of spores, suggesting that they may serve as potential targets for the design of anti-anthrax vaccines and drugs.

原文???core.languages.en_GB???
頁(從 - 到)143-151
頁數9
期刊Genomics, proteomics & bioinformatics / Beijing Genomics Institute
2
發行號3
DOIs
出版狀態已出版 - 8月 2004

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