@article{d0ae79b9d06c44838bb00e3c40c9c0d3,
title = "Proteogenomic Characterization of Endometrial Carcinoma",
abstract = "We undertook a comprehensive proteogenomic characterization of 95 prospectively collected endometrial carcinomas, comprising 83 endometrioid and 12 serous tumors. This analysis revealed possible new consequences of perturbations to the p53 and Wnt/β-catenin pathways, identified a potential role for circRNAs in the epithelial-mesenchymal transition, and provided new information about proteomic markers of clinical and genomic tumor subgroups, including relationships to known druggable pathways. An extensive genome-wide acetylation survey yielded insights into regulatory mechanisms linking Wnt signaling and histone acetylation. We also characterized aspects of the tumor immune landscape, including immunogenic alterations, neoantigens, common cancer/testis antigens, and the immune microenvironment, all of which can inform immunotherapy decisions. Collectively, our multi-omic analyses provide a valuable resource for researchers and clinicians, identify new molecular associations of potential mechanistic significance in the development of endometrial cancers, and suggest novel approaches for identifying potential therapeutic targets.",
keywords = "CTNNB1, TP53, acetylation, circular RNA, endometrial cancer, endometrioid endometrial cancer, immune evasion, proteogenomics, proteomics, serous endometrial cancer",
author = "{the Clinical Proteomic Tumor Analysis Consortium} and Yongchao Dou and Kawaler, {Emily A.} and {Cui Zhou}, Daniel and Gritsenko, {Marina A.} and Chen Huang and Lili Blumenberg and Alla Karpova and Petyuk, {Vladislav A.} and Savage, {Sara R.} and Shankha Satpathy and Wenke Liu and Yige Wu and Tsai, {Chia Feng} and Bo Wen and Zhi Li and Song Cao and Jamie Moon and Zhiao Shi and MacIntosh Cornwell and Wyczalkowski, {Matthew A.} and Chu, {Rosalie K.} and Suhas Vasaikar and Hua Zhou and Qingsong Gao and Moore, {Ronald J.} and Kai Li and Sunantha Sethuraman and Monroe, {Matthew E.} and Rui Zhao and David Heiman and Karsten Krug and Karl Clauser and Ramani Kothadia and Yosef Maruvka and Pico, {Alexander R.} and Oliphant, {Amanda E.} and Hoskins, {Emily L.} and Pugh, {Samuel L.} and Beecroft, {Sean J.I.} and Adams, {David W.} and Jarman, {Jonathan C.} and Andy Kong and Chang, {Hui Yin} and Boris Reva and Yuxing Liao and Dmitry Rykunov and Antonio Colaprico and Chen, {Xi Steven} and Andrzej Czeka{\'n}ski and Marcin J{\c e}dryka",
note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
month = feb,
day = "20",
doi = "10.1016/j.cell.2020.01.026",
language = "???core.languages.en_GB???",
volume = "180",
pages = "729--748.e26",
journal = "Cell",
issn = "0092-8674",
number = "4",
}