Protein tyrosine phosphatases and their inhibitors

Purushottam M. Dewang, Nai Mu Hsu, Shao Zheng Peng, Wen Ren Li

研究成果: 雜誌貢獻回顧評介論文同行評審

46 引文 斯高帕斯(Scopus)

摘要

Protein tyrosine phosphatase (PTP) is the family of enzymes that are key players in cellular signal transduction system and perturbation in their functioning is implicated in many disease-states. Diverse chemical compounds are being synthesized and evaluated as PTP inhibitors. This review presents a brief account of various enzymes of the PTP family and their inhibitors. Peculiar features of these enzymes and their roles in various diseases are summarized along with important inhibitors developed in recent years.

原文???core.languages.en_GB???
頁(從 - 到)1-22
頁數22
期刊Current Medicinal Chemistry
12
發行號1
DOIs
出版狀態已出版 - 2005

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