Protection from oxidative damage using Bidens pilosa extracts in normal human erythrocytes

Hsin Ling Yang, Ssu Ching Chen, Nai Wen Chang, Jia Ming Chang, Mei Ling Lee, Pei Chuan Tsai, Han Hsuan Fu, Wei Wan Kao, Hsiao Chi Chiang, Hsuan Hui Wang, You Cheng Hseu

研究成果: 雜誌貢獻期刊論文同行評審

105 引文 斯高帕斯(Scopus)

摘要

Bidens pilosa (B. pilosa) is well known in Taiwan as a traditional Chinese medicine. The purpose of this study was to evaluate the ability of both the ethanol (EtOH) and ethylacetate/ethanol (EA/EtOH) extracts from the whole B. pilosa plant, to protect normal human erythrocytes against oxidative damage in vitro. It was determined that the oxidative hemolysis and lipid/protein peroxidation of erythrocytes induced by the aqueous peroxyl radical [2,2′-azobis(2-amidinopropane) dihydrochloride (AAPH)] were suppressed by both EtOH (50-150 μg/ml) and EA/EtOH (25-75 μg/ml) extracts of B. pilosa in concentration- and time-dependent manners. B. pilosa extracts also prevented the decline of superoxide dismutase (SOD) activity and the depletion of cytosolic glutathione (GSH) and ATP in erythrocytes. These results imply that B. pilosa may have protective antioxidant properties.

原文???core.languages.en_GB???
頁(從 - 到)1513-1521
頁數9
期刊Food and Chemical Toxicology
44
發行號9
DOIs
出版狀態已出版 - 9月 2006

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