每年專案
摘要
Judiciously tuning heart rates is critical for regular cardiovascular function. The fractal pattern of heartbeats-a multiscale regulation in instantaneous fluctuations-is well known for vertebrates. The most primitive heart system of the Drosophila provides a useful model to understand the evolutional origin of such a fractal pattern as well as the alterations of fractal pattern during diseased statuses. We developed a non-invasive visible optical heart rate recording system especially suitable for long-term recording by using principal component analysis (PCA) instead of fluorescence recording system to avoid the confounding effect from intense light irradiation. To deplete intracellular Ca 2+ levels, the expression of sarco-endoplasmic reticulum Ca 2+ -ATPase (SERCA) was tissue-specifically knocked down. The SERCA group shows longer heart beat intervals (Mean ± SD: 1009.7 ± 151.6 ms) as compared to the control group (545.5 ± 45.4 ms, p < 0.001). The multiscale correlation of SERCA group (scaling exponent: 0.77 ± 0.07), on the other hand, is weaker than that of the control Drosophila (scaling exponent: 0.85 ± 0.03) (p = 0.016).
原文 | ???core.languages.en_GB??? |
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文章編號 | 31950 |
期刊 | Scientific Reports |
卷 | 6 |
DOIs | |
出版狀態 | 已出版 - 18 8月 2016 |
指紋
深入研究「Probing the fractal pattern of heartbeats in drosophila pupae by visible optical recording system」主題。共同形成了獨特的指紋。專案
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