Preparation and hemocompatibility of surface-modified membranes

When blood is applied to biomaterials, there is an initial adsorption of serum proteins. This is followed by platelet adhesion and activation of coagulation pathways, leading to thrombus formation. Several surface-modified polysulfone (PSf) hollow fibers were prepared with chemical modification. In this study, the polymerization of Vinylpyrrolidone (VP) and zwitterionic monomer of N,N-dimethyl-N-methacryloxyethyl-N-(3-sulfopropyl)ammonium betaine (SPE) on the surface of the polysulfone hollow fibers is reported. Platelet adhesion and serum protein adsorption on the polysulfone membranes conjugated with SPE and VP polymer on the surface from human plasma are investigated. It is suggested that the hydrophilic segments on the hydrophobic surface will cause the suppression of platelet adhesion and plasma protein adsorption.