Porphyrin metabolisms in human skin commensal propionibacterium acnes bacteria: Potential application to monitor human radiation risk

M. Shu, S. Kuo, Y. Wang, Y. Jiang, Y. T. Liu, R. L. Gallo, C. M. Huang

研究成果: 雜誌貢獻期刊論文同行評審

57 引文 斯高帕斯(Scopus)

摘要

Propionibacterium acnes (P. acnes), a Gram-positive anaerobic bacterium, is a commensal organism in human skin. Like human cells, the bacteria produce porphyrins, which exhibit fluorescence properties and make bacteria visible with a Wood's lamp. In this review, we compare the porphyrin biosynthesis in humans and P. acnes. Also, since P. acnes living on the surface of skin receive the same radiation exposure as humans, we envision that the changes in porphyrin profiles (the absorption spectra and/or metabolism) of P. acnes by radiation may mirror the response of human cells to radiation. The porphyrin profiles of P. acnes may be a more accurate reflection of radiation risk to the patient than other biodosimeters/biomarkers such as gene up-/down-regulation, which may be non-specific due to patient related factors such as autoimmune diseases. Lastly, we discuss the challenges and possible solutions for using the P. acnes response to predict the radiation risk.

原文???core.languages.en_GB???
頁(從 - 到)562-568
頁數7
期刊Current Medicinal Chemistry
20
發行號4
DOIs
出版狀態已出版 - 2月 2013

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