TY - JOUR
T1 - Pegylated Metal-Phenolic Networks for Antimicrobial and Antifouling Properties
AU - Zheng, Hsiao Tung
AU - Bui, Hoang Linh
AU - Chakroborty, Subhendu
AU - Wang, Yi
AU - Huang, Chun Jen
N1 - Publisher Copyright:
© 2019 American Chemical Society.
PY - 2019/7/2
Y1 - 2019/7/2
N2 - Metal-phenolic networks (MPNs) have recently attracted great interest in material chemistry and biomaterials because of their biocompatible, versatile, and multifunctional properties. In this paper, we describe a facile method for preparation of a designable antifouling, antimicrobial, and substrate-independent coating assembled from the coordination of metal ions and catecholic groups. Hydrophilic and catecholic polymers were synthesized by copolymerization of dopamine methacrylamide (DMA) and poly(ethylene glycol)methyl methacrylate (PEGMA) to afford p(PEGMA-co-DMA). To investigate the assembly and formation of MPN films, two different metal ions, that is, ferrous (FeII) and ferric (FeIII) ions, to react with p(PEGMA-co-DMA) were compared. The binding constants between iron ions and p(PEGMA-co-DMA) have been investigated by ultraviolet-visible spectroscopy (UV-vis). Measurements with atomic force microscopy, contact angle goniometer, and X-ray photoelectron spectroscopy (XPS) were carried out to quantitatively analyze the surface morphology, wettability, and interfacial elemental compositions of coatings, respectively. Moreover, ellipsometric measurements were performed to obtain the film thickness and grafting density. In addition, the pH-responsive property of the MPN films was investigated at different pH values, showing fast disassembly of the networks at low pH. The antifouling properties of the obtained coatings were analyzed by exposing them to bacteria of Escherichia coli and Staphylococcus epidermidis and NIH-3T3 fibroblasts under observation of fluorescence microscopy and cell imaging analysis. The findings suggest that the MPN from complexation of p(PEGMA-co-DMA) and metal ions provides excellent antifouling, pH-responsive, and biocompatible properties on a wide range of substrates. Furthermore, the released iron ions can effectively suppress the growth of bacteria. Accordingly, the new coating architecture offers a universal feature to control surface properties and functionalization for various applications.
AB - Metal-phenolic networks (MPNs) have recently attracted great interest in material chemistry and biomaterials because of their biocompatible, versatile, and multifunctional properties. In this paper, we describe a facile method for preparation of a designable antifouling, antimicrobial, and substrate-independent coating assembled from the coordination of metal ions and catecholic groups. Hydrophilic and catecholic polymers were synthesized by copolymerization of dopamine methacrylamide (DMA) and poly(ethylene glycol)methyl methacrylate (PEGMA) to afford p(PEGMA-co-DMA). To investigate the assembly and formation of MPN films, two different metal ions, that is, ferrous (FeII) and ferric (FeIII) ions, to react with p(PEGMA-co-DMA) were compared. The binding constants between iron ions and p(PEGMA-co-DMA) have been investigated by ultraviolet-visible spectroscopy (UV-vis). Measurements with atomic force microscopy, contact angle goniometer, and X-ray photoelectron spectroscopy (XPS) were carried out to quantitatively analyze the surface morphology, wettability, and interfacial elemental compositions of coatings, respectively. Moreover, ellipsometric measurements were performed to obtain the film thickness and grafting density. In addition, the pH-responsive property of the MPN films was investigated at different pH values, showing fast disassembly of the networks at low pH. The antifouling properties of the obtained coatings were analyzed by exposing them to bacteria of Escherichia coli and Staphylococcus epidermidis and NIH-3T3 fibroblasts under observation of fluorescence microscopy and cell imaging analysis. The findings suggest that the MPN from complexation of p(PEGMA-co-DMA) and metal ions provides excellent antifouling, pH-responsive, and biocompatible properties on a wide range of substrates. Furthermore, the released iron ions can effectively suppress the growth of bacteria. Accordingly, the new coating architecture offers a universal feature to control surface properties and functionalization for various applications.
UR - http://www.scopus.com/inward/record.url?scp=85068032252&partnerID=8YFLogxK
U2 - 10.1021/acs.langmuir.9b01196
DO - 10.1021/acs.langmuir.9b01196
M3 - 期刊論文
C2 - 31177783
AN - SCOPUS:85068032252
VL - 35
SP - 8829
EP - 8839
JO - Langmuir
JF - Langmuir
SN - 0743-7463
IS - 26
ER -