Particle Size and Crystal Habit Modification of Active Pharmaceutical Ingredient Using Cooling Sonocrystallization: A Case Study of Probenecid

Chemical Compounds

• Probenecid 100%
• Crystal Habit 83%
• Cooling 57%
• Pharmaceutical 47%
• Modification 36%
• Sonication 33%
• Solvent 30%
• Ethanol 21%
• Solubility 20%
• Crystal Morphology 16%
• Size Distribution 14%
• Organic Solvent 11%
• X-Ray 9%
• Fourier Transform Infrared Spectroscopy 9%
• Reaction Yield 6%

Engineering & Materials Science

• Drug products 71%
• Crystals 64%
• Particle size 61%
• Cooling 45%
• Sonication 32%
• Solubility 23%
• Ethanol 21%
• Organic solvents 15%
• Diffractometers 14%
• Fourier transform infrared spectroscopy 13%
• X rays 9%
• Ultrasonics 9%
• Powders 8%
• Throughput 7%
• Recovery 7%
• Experiments 3%

Physics & Astronomy

• habits 79%
• ingredients 67%
• cooling 44%
• crystals 31%
• ethyl alcohol 21%
• solubility 19%
• diffractometers 11%
• trucks 11%
• infrared spectroscopy 9%
• recovery 8%
• x rays 4%