Palladium-Catalyzed Allylic Substitution for the Synthesis of Pericosines

Cheng Yu Chung, Venkatachalam Angamuthu, Long Shiang Li, Duen Ren Hou

研究成果: 雜誌貢獻期刊論文同行評審

1 引文 斯高帕斯(Scopus)

摘要

A sequence of vinylalumination of α-substituted aldehydes, ring-closing metathesis (RCM), and palladium-catalyzed allylic substitution was utilized to prepare the biologically active natural products, pericosines, from d-ribose. The anti-adduct of vinylalumination was transformed into pericosine A after RCM, removal of the 4-methoxybenzyl protecting group, and chlorination. The diacetate of the anti-adduct was converted to pericosine C after the palladium-catalyzed, SN2′-type, allylic substitution. However, an unexpected dimeric product was generated in utilizing this approach to prepare pericosine E.

原文???core.languages.en_GB???
頁(從 - 到)1327-1333
頁數7
期刊Asian Journal of Organic Chemistry
5
發行號11
DOIs
出版狀態已出版 - 1 11月 2016

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