Optical measurement of the viscoelastic and biochemical responses of living cells to mechanical perturbation

Chau Hwang Lee, Chin Lin Guo, Jyhpyng Wang

研究成果: 雜誌貢獻期刊論文同行評審

36 引文 斯高帕斯(Scopus)

摘要

We have developed an optical method for real-time monitoring of cellular motion in a natural environment with nanometer resolution. From the motion driven by small optical forces, we measured dynamic viscoelastic responses of living cells in the linear reversible region. Cytoplasmic gel-to-sol transition that was due to the disruption of the actin-filament framework was detected, and a linear release of Ca2+ from intracellular storage that was related to submicrometer cell deformation was observed. The method was shown to be a powerful tool for studying the natural response of cells to mechanical perturbation.

原文???core.languages.en_GB???
頁(從 - 到)307-309
頁數3
期刊Optics Letters
23
發行號4
DOIs
出版狀態已出版 - 15 2月 1998

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