Optical immuno-biochip for detection of oral cancer biomarkers with IoT platform

Hsiang Yu Lei, Zhi Zhong Wang, Yi Chun Chen, Chia Sheng Kuo, Can Hua Yang, Chen Han Huang

研究成果: 書貢獻/報告類型會議論文篇章同行評審

1 引文 斯高帕斯(Scopus)


Oral cavity cancer is one of the most common malignancies. Development of immunoassay based biosensor for interleukin-8 (IL-8) protein is required. The miniaturization of the device is also necessary in order to provide ready-touse portable diagnostic tools (point of care diagnostic) for clinical uses. In the current study, a compact, portable and reliable biomarker detecting and analyzing system is presented. The light absorption analysis was performed by a low-cost and portable optical sensor device. We used a programmable microcontroller unit (MCU) to operate the device. A digitalto-analog converter (DAC) was used to deliver a modulating signal to LEDs, and then the modulated light excited the samples in the microfluidic detection chamber. The signals from the sample and control group were obtained by two photodetectors individually. The photodetectors were amplified and demodulated through the lock-in amplifier, and digitized by analog-to-digital converters (ADC) to the MCU. After that, the analyzed data was uploaded to the smartphone via Bluetooth. The device demonstrates a good measurement accuracy and shorter detection time compared to conventional methods.

主出版物標題Microfluidics, BioMEMS, and Medical Microsystems XVIII
編輯Bonnie L. Gray, Holger Becker
出版狀態已出版 - 2020
事件Microfluidics, BioMEMS, and Medical Microsystems XVIII 2020 - San Francisco, United States
持續時間: 1 2月 20204 2月 2020


名字Progress in Biomedical Optics and Imaging - Proceedings of SPIE


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國家/地區United States
城市San Francisco


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