TY - JOUR
T1 - Optical biosensors based on four different surface plasmon resonance modes
T2 - Plasmonics in Biology and Medicine
AU - Chien, F. C.
AU - Chen, S. J.
N1 - Funding Information:
The current authors wish to acknowledge the financial support provided to this study by the Ministry of Education, Taiwan under Grant No. A-91-E-FA08-1-4.
PY - 2004
Y1 - 2004
N2 - Current surface plasmon resonance (SPR) modes based on the attenuated total reflection (ATR) method can broadly be categorized as: conventional SPR, long-range SPR (LRSPR), coupled plasmon-waveguide resonance (CPWR), and waveguide-coupled SPR (WCSPR). Although the features of optical biosensors are dependent upon their particular SPR mode, a common requirement for all biosensors utilized for biomolecular interaction analysis (BIA) is a high degree of sensitivity. The current paper presents a theoretical analysis and comparison of the sensitivity and resolution of these four types of SPR biosensors when employed in three of the most prevalent detection methods, namely angular interrogation, wavelength interrogation, and intensity measurement. This study develops a detailed understanding of the influences of various biosensor design parameters in order to enhance the sensitivity and detection limit capabilities of such devices.
AB - Current surface plasmon resonance (SPR) modes based on the attenuated total reflection (ATR) method can broadly be categorized as: conventional SPR, long-range SPR (LRSPR), coupled plasmon-waveguide resonance (CPWR), and waveguide-coupled SPR (WCSPR). Although the features of optical biosensors are dependent upon their particular SPR mode, a common requirement for all biosensors utilized for biomolecular interaction analysis (BIA) is a high degree of sensitivity. The current paper presents a theoretical analysis and comparison of the sensitivity and resolution of these four types of SPR biosensors when employed in three of the most prevalent detection methods, namely angular interrogation, wavelength interrogation, and intensity measurement. This study develops a detailed understanding of the influences of various biosensor design parameters in order to enhance the sensitivity and detection limit capabilities of such devices.
KW - Biomolecular interaction analysis
KW - Conventional surface plasmon resonance
KW - Coupled plasmon-waveguide resonance
KW - Long-range surface plasmon resonance
KW - Waveguide-coupled surface plasmon resonance
UR - http://www.scopus.com/inward/record.url?scp=7644229881&partnerID=8YFLogxK
U2 - 10.1117/12.530434
DO - 10.1117/12.530434
M3 - 會議論文
AN - SCOPUS:7644229881
SN - 0277-786X
VL - 5327
SP - 148
EP - 159
JO - Proceedings of SPIE - The International Society for Optical Engineering
JF - Proceedings of SPIE - The International Society for Optical Engineering
Y2 - 26 January 2004 through 27 January 2004
ER -