On the possible origin of bulk third harmonic generation in skin cells

Tung Yu Su; Chien Sheng Liao; Chih Yuan Yang; Guan Yu Zhuo; Szu Yu Chen; Shi Wei Chu

doi:10.1063/1.3638458

On the possible origin of bulk third harmonic generation in skin cells

Tung Yu Su, Chien Sheng Liao, Chih Yuan Yang, Guan Yu Zhuo, Szu Yu Chen, Shi Wei Chu

光電科學與工程學系

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

3 引文斯高帕斯（Scopus）

摘要

We studied third harmonic generation (THG) of melanin solution with concentrations similar to melanocytes in human skin. In contrast to conventional observation of THG at interface, bulk THG was detected inside the solution due to the formation of melanin hydrocolloids. A linear relationship between melanin concentration and THG intensity was found, suggesting THG originated from high-order hyper-Rayleigh scattering. By fitting this linear relationship, third-order hyperpolarizability of melanin hydrocolloids was determined to be three orders larger than that of water. Our result will be useful for interpretation of THG signals in skin and other tissues containing colloidal particles.

原文	???core.languages.en_GB???
文章編號	113702
期刊	Applied Physics Letters
卷	99
發行號	11
DOIs	https://doi.org/10.1063/1.3638458
出版狀態	已出版 - 12 9月 2011

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title = "On the possible origin of bulk third harmonic generation in skin cells",

abstract = "We studied third harmonic generation (THG) of melanin solution with concentrations similar to melanocytes in human skin. In contrast to conventional observation of THG at interface, bulk THG was detected inside the solution due to the formation of melanin hydrocolloids. A linear relationship between melanin concentration and THG intensity was found, suggesting THG originated from high-order hyper-Rayleigh scattering. By fitting this linear relationship, third-order hyperpolarizability of melanin hydrocolloids was determined to be three orders larger than that of water. Our result will be useful for interpretation of THG signals in skin and other tissues containing colloidal particles.",

author = "Su, {Tung Yu} and Liao, {Chien Sheng} and Yang, {Chih Yuan} and Zhuo, {Guan Yu} and Chen, {Szu Yu} and Chu, {Shi Wei}",

note = "Funding Information: The authors would like to acknowledge Professor C. K. Sun{\textquoteright}s generous support. The project is supported by National Science Council (NSC-98-2112-M-002-003-MY3, NSC 98-2738-M-002-001) and National Taiwan University (98R0321). ",

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AU - Liao, Chien Sheng

AU - Yang, Chih Yuan

AU - Zhuo, Guan Yu

AU - Chen, Szu Yu

AU - Chu, Shi Wei

N1 - Funding Information: The authors would like to acknowledge Professor C. K. Sun’s generous support. The project is supported by National Science Council (NSC-98-2112-M-002-003-MY3, NSC 98-2738-M-002-001) and National Taiwan University (98R0321).

PY - 2011/9/12

Y1 - 2011/9/12

N2 - We studied third harmonic generation (THG) of melanin solution with concentrations similar to melanocytes in human skin. In contrast to conventional observation of THG at interface, bulk THG was detected inside the solution due to the formation of melanin hydrocolloids. A linear relationship between melanin concentration and THG intensity was found, suggesting THG originated from high-order hyper-Rayleigh scattering. By fitting this linear relationship, third-order hyperpolarizability of melanin hydrocolloids was determined to be three orders larger than that of water. Our result will be useful for interpretation of THG signals in skin and other tissues containing colloidal particles.

AB - We studied third harmonic generation (THG) of melanin solution with concentrations similar to melanocytes in human skin. In contrast to conventional observation of THG at interface, bulk THG was detected inside the solution due to the formation of melanin hydrocolloids. A linear relationship between melanin concentration and THG intensity was found, suggesting THG originated from high-order hyper-Rayleigh scattering. By fitting this linear relationship, third-order hyperpolarizability of melanin hydrocolloids was determined to be three orders larger than that of water. Our result will be useful for interpretation of THG signals in skin and other tissues containing colloidal particles.

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On the possible origin of bulk third harmonic generation in skin cells

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